ABSTRACT
In order to study placental transfer of IgG subclasses, paired blood samples were collected from mothers and umbilical cord of preterm (N = 69) and full-term (N = 68) newborns. The full-term group was further divided into 3 subgroups: appropriate for gestational age (AGA, N = 43), large for gestational age (LGA, N = 13) and small for gestational age (SGA, N = 12), according to birth weight. IgG subclasses (IgG1, IgG2, IgG3 and IgG4) were measured by the single radial immunodiffusion technique using monoclonal antibodies. IgG1 and IgG3 newborn subclass concentrations (10.17 and 0.57 g/l, respectively) increased with increasing gestational age and reached maternal levels (IgG1 = 8.86; IgG3 = 0.67 g/l) during the 37th week of pregnancy. Low levels of these subclasses were found in premature newborns. IgG2 from newborns were always lower than maternal levels (P<0.05). LGA and SGA newborns had equivalent levels of IgG1 and IgG2 compared with AGA. SGA newborns had higher levels of IgG3 and lower levels of IgG4 than LGA and AGA newborns.
Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Immunization, Passive , Immunoglobulin G/blood , Infant, Premature/blood , Placenta/physiology , Infant, Newborn/blood , Immunoglobulin G/classification , Placenta/immunology , Receptors, FcABSTRACT
O forcipe e instrumento do arsenal obstetrico desde ha centurias. No decorrer dos tempos foi sendo aprimorado sob varios angulos. As codificacoes de Magalhaes e o postulado De Lee deram a pinca de Chamberlen novo conceito Nao pode, e nao deve ser proscrito visto que e de grande serventia em determinadas indicacoes materno-fetais. E tao prestimoso que ha servicos, mormente nos Estados Unidos, onde seu emprego e a basto na abreviacao do periodo expulsivo. Os A.A. estudam-no e comentam as 175 aplicacoes do forcipe na Maternidade Carmela Dutra, num total de 5436 partos ocorridos desde lo. de janeiro ate 31 de dezembro de 1980, na incidencia de 3,2%