ABSTRACT
A study was conducted in mid hill region of Rajouri district, J&K, India to analyze the impact lockdown amid covid-19 pandemic on weather parameters. Day and night temperature readings were recorded fortnightly from 1st March to 30th June 2020 from maximum and minimum thermometer, rainfall values from ordinary rain gauge, and soil temperature at different depth from soil thermometers and values were compared with data from 2017-2019 and normal. After analyzing the data statistically using “Descriptive statistics” in MS-Excel 2010, it was observed that within the period of lockdown, the change in day temperature was -6.66% from normal mean value, however night temperature was least affected as it changes 10.33% and rainfall pattern was 19.27% more from normal mean value. The average change in soil temperature in morning at 5 cm, 10 cm and 20 cm depth in lockdown was -4.65%, 3.74% and 2.65% as compared to year 2019 (1st March to 30th June) mean value and the change in soil temperature in evening at same depths was -5.14%, -11.30% and 0.3% from year 2019 (1st March to 30th June) depicting a slow change in values. With the significant sustainable pattern observed in day and soil temperature parameters and rainfall it can be concluded that lockdown might be an effective tool in reducing speed of climate change in future.
ABSTRACT
Aim: A study was conducted in mid hill region of Jammu district, J&K to analyze the impact lockdown amid covid-19 pandemic on weather parameters so as to define it as a tool to mitigate the pace of climate change. Methodology: Day and night temperature readings were recorded fortnightly during 22nd March to 10th June 2020 from maximum and minimum thermometer, relative humidity from dry and wet bulb thermometers in stevenson screen, rainfall values from ordinary rain gauge, evaporation readings from pan evaporimeter and soil temperature at different depth from soil thermometers. Results: After analyzing the data statistically using “Descriptive statistics” in MS-Excel 2010, it was observed that after the implementation of lockdown and with the beginning of unlock down the change in day temperature was -8.07% from normal mean value, night temperature was -4.44% from normal mean value, rainfall pattern was 30.00% more from normal mean value, Relative Humidity (morning) pattern was 6.94% more from normal mean value, relative humidity (evening) pattern was 20.94% more from normal mean value, evaporation pattern was 7.66% more from normal mean value. The average change in soil temperature in morning at 5 cm, 10 cm and 20 cm depth was -3.46%, -3.84% and -7.23% as compared to year 2019 (22nd March to 10th June 2019) mean value and the change in soil temperature in evening at same depths was -7.69%, -6.31% and -4.14% from year 2019 (22nd March to 10th June 2019). Conclusion: With the variable significant pattern observed in almost all parameters, it can be concluded that lockdown might be an effective tool in mitigating pace of climate change in future.
ABSTRACT
Background: Kshara is an important dosage form mentioned in Ayurveda which is derived from plant ash. The Kshara have some similar properties like alkaline nature, water solubility, whitish color etc. Kshara are given advantage over all surgical and parasurgical measures as it can be used in thin, weak and patients who fears for surgery. Different herbs like Apamarga, Snuhi, Kadalipalasha are used to prepare Kshara either single or collectively in classical texts. Therapeutic use of Kshara of different herbs differs from each other hence analytical study of each Kshara is necessary. Aims & Objectives: In the present study preparation of Palash (Butea monosperma) kshara and analytical study is done to understand the characteristics of Palashkshara. Material & methods: The preparation of Kshara is a multistep procedure. In the present study preparation of Palasha Kshara is done according general method of preparation of Kshara mentioned in Sharangadhara Sanhita. Prepared Kshara is subjected to various Physico chemical analyses and results are concluded. Results: The Palash Kshara shows physical properties like whitish in color, pungent odor and soft in touch. Chemically it shows combination of Potassium, Phosphate and Sulphate along with other elements in traces. The present study gives the details of methodology and results of the pharmaceutical and analytical study of Palash Kshara.
ABSTRACT
Fungal brain abscess is rare with a rapidly progressive disease with fulminant course and invariably fatal outcome, unless diagnosed early and treated rapidly. We report a 56‑year‑old woman diagnosed to have fungal abscess who recovered completely following amphotericin B treatment. She presented with weakness of the right hand, deviation of mouth to left and aphasia for 2 days. Computed tomography of the brain revealed a left frontal capsuloganglionic hypodense lesion. Stereotactic biopsy was performed, and microbiological confirmation of non‑septate fungal hyphae from pus from aspirate within 2 h helped initiate timely and appropriate treatment leading to cure. Histopathology and culture later confirmed mucormycosis.
ABSTRACT
Aims: To formulate fast dissolving tablets of amlodipine besylate using co-processed superdisintigrant and evaluate the properties of fast dissolving tablets. Study Design: Formulation, evaluation of fast dissolving tablets of amlodipine besylate. Place and Duration of Study: Department of Quality Assurance S. N. D. College of Pharmacy Babhulgoan Yeola Dist Nashik 423401, between July 2012 to February 2013. Methodology: In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and sodium starch glycolate in different ratios (1:1, 1:2 1:3 2:1, 3:1) in the fast dissolving tablet formulations. Drug and the developed excipients were characterized for compatibility studies with FTIR and DSC. The co-processed superdisintigrant mixture was evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. Fast dissolving tablets of Amlodipine Besylate were prepared using co-processed superdisintegrants and evaluated for pre-compression and postcompression parameters. Effect of co-processed superdisintegrants (crospovidone and sodium starch glycolate) on wetting time, disintegrating time, drug content, in-vitro release, and stability parameters have been studied. Results: The angle of repose of the developed excipients was found to be < 300 Compressibility (%) index in the range of 13.14 to 14.63 % and Hausner’s ratio in the range of 1.15-1.19. The prepared tablets were characterized by FTIR and DSC Studies there was no change in the result. Based on in-vitro dispersion time (approximately 40 sec), promising formulation CP5 was tested for in-vitro drug release pattern in phosphate buffer pH 6.8. Conclusion: Among the designed formulations, the formulation (CP5) containing coprocessed superdisintegrant (3:1 mixture of crospovidone and sodium starch glycolate) emerged as the overall best formulation based on drug release characteristics in phosphate buffer pH 6.8. From this study, it can be concluded that dissolution rate of amlodipine besylate could be enhanced by tablets containing co-processed superdisintegrant.