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Background : Lipid Peroxidation (LPO) plays a major initiative factor of cataractogenesis in both age-related or senile cataract and Diabetic cataract. Recently, 8-isoprostaglandin F2? (8-iso-PGF2?) is a reliable biomarker of in-vivo LPO and used as potential indicator of oxidative stress. However, serum 8-iso-PGF2? concentration and its association with glycemic control (HbA1c) in the pathogenesis of diabetic cataract subjects are still unknown. Objectives : The present study was designed to estimate 8-iso-PGF2? and antioxidant enzymes levels in serum of Type 2 Diabetes Mellitus patients with senile cataract compared to healthy individuals without cataract as control. To assess the magnitude of the association between 8-iso-PGF2? and glycemic status in diabetic cataract. Materials and Methods : 60 Diabetic Senile Cataracts (DSC) and 60 healthy individuals without cataract in the age group between 45-75 years of both genders. 8-iso-PGF2?, Superoxide Dismutase [Cu-Zn] (SOD3) and Catalase (CAT) concentration were estimated in serum by ELISA method. Results : The mean concentration of 8-iso-PGF2? was significantly increased (541.6±142.7 pg/ml, p<0.001) and mean concentration of SOD3 (102.1±32.8 ng/ml, p=0.007) and Catalase (1005±274.5 IU/ml, p<0.001) were significantly decreased in serum of diabetic senile cataract when compared to healthy individuals without cataract (control). A negative correlation between serum 8-iso-PGF2? and SOD3 and positive correlation between serum 8- iso-PGF2? and fasting blood glucose were observed in Diabetic Senile Cataracts. Conclusion : The present findings indicate that increased 8-iso-PGF2? is associated with oxidative stress which plays a significant role in the pathogenesis of cataract in diabetic patients
ABSTRACT
Identity and legal culpability hinges on age estimation in modern society. There are several biometric methods for accurate age determination that have validity in medico-legal proceedings globally. The accuracy of conventional methods should be reassessed periodically to ascertain validity in differing global societies. This study aims to evaluate the comparative accuracy of three age determination methods based on non-invasive radiographic odontometric data when applied to a sample of Saudi population. MethodsThis cross-sectional study is done on 350 subjects of Saudi Arabian population, aged between 4 and 16 years. The same set of radiographs is used in all three methods and the dental age estimation is done by trained examiners who determine the age using Demirjian’s, Willem’s and the London Atlas Method. Statistical analysis is done using the IBM SPSS (Statistical Package for Social Science) software (version 19). Significance of differences between the chronological age and the estimated dental age was calculated using paired ‘t’ test (P value of < 0.05 was considered significant. ResultsThe chronological age was above estimated age by all three methods used to assess male samples. Significant difference was seen with William's method (p=0.000) and the the London Atlas Method (p=0.000), and no significant difference was seen with Demirjian's method (p=0.102). Demirjian's method estimated the age above chronological age for females while the other two methods were below in their estimates. There were significant differences only between the London Atlas estimates and chronological age in females (p = 0.020). ConclusionsAge estimated by Demirjian’s method on Saudi population is most accurate among the methods tested. Boys showed more variations than girls when the ages were measured. Changing diet and socioeconomic factors influence growth and development of children, and this can alter the anticipated outcomes of age determination by mathematical methods.
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Background: Febrile seizure (FS) is the most common cause of seizure in children, occurring between 6-60 months. It coincides with peak age of incidence for Iron deficiency anemia (IDA). Iron is required for optimal growth and development and its deficiency is associated with numerous problems including persistent cognitive and motor delays. The objective was to study the role of IDA as a risk factor for simple febrile seizure and its recurrenceMethods: A case control study was conducted among 90 febrile children - 45 cases with simple febrile seizure and 45 cases with febrile illness, between the age group of six months to five years of age at Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, between September 2013 and June 2015. The hematological parameters like Hemoglobin, Serum ferritin and RDW were compared between the two groups with respect to fever and different temperature intervals, recurrence of FS.Results: Hb and Serum Ferritin levels were found to be significantly associated with simple febrile seizure, with p value of <0.002 and 0.001 respectively. Similar association was found at different temperature intervals. However, there was no association of hematological parameters with FS recurrence.Conclusions: IDA is a significant risk factor for FS in children while same may not have any effect on the recurrence of FS.
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Background: Pleural effusions commonly occur in patients with advanced cancer and tuberculosis. Pleural aspiration by the conventional tube thoracostomy using large bore chest tube-intercostal drain (ICD) - can often cause discomfort to patients. The aim of this study is to compare the efficacy of drainage of pleural effusions using flexible small bore Pleural Catheter (PC) and ICD. Methods: In this prospective study, 101 patients (age 16-65 years) with pleural effusions were divided into PC (n=60) and ICD (n=41) groups. Responses were evaluated and analyzed statistically. Results: The PC group was equally efficacious as ICD with regard to complete re-expansion of lung. The most common complication in the PC group was block (9/60 i.e. 15%). Difference in the mean number of days on drain in the PC (4.9 days) and ICD group (5.8 days) as well as the mean number of times analgesics administered in the PC (2.85 days) and the ICD group (7.53 days) were statistically significant (p <0.05). Similarly, the complications such as surgical emphysema, haemorrhage, desaturation and hypotension were high in the conventional group when compared to that of PC group (p <0.05). Conclusions: Flexible small bore intercostal catheter is a valid and safe option for drainage of pleural effusion when compared to the conventional tube thoracostomy.
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Background: Allium sativum was known to possess antibacterial activity because of the presence of allic acid in its bulbs. Aim: To compare and evaluate the smear layer removal capacity of 3% NaOCl, 2% Allium sativum, 17% EDTA and saline. Methodology: Forty one extracted teeth were collected and the root canals were instrumented with protaper till F3 size. During root canal preparation, irrigations were made with the different solutions being evaluated and the roots were cut in the buccolingual direction for SEM analysis, to ascertain the presence or absence of smear layer and debris. Statistical analysis: Pearson’s chi-square test and fisher exact test were used. Results: In the coronal and middle thirds, Group I produced a synergistic effect, resulting in effective removal of the entire smear layer. Group II has good smear layer removal also. Conclusion: Allium sativum does have an effect on the removal of smear layer when used as endodontic irrigant.