ABSTRACT
Background: The incidents of CAD is increasing alarmingly and evidence is emerging about the role of novel risk factors. hs-CRP is emerging as a crucial risk factor for premature atherothrombosis and cardio vascular events. Elevated hs- CRP concentrations early in Acute Coronary Syndrome (ACS), prior to the tissue necrosis, may be a surrogate marker for cardiovascular co-morbidities. Aim: This study was undertaken to measure the levels of serum hs-CRP in patients with CAD as established by CAG. Materials and methods: This study included 100 patients admitted in General Medicine and Cardiology departments with a spectrum of coronary artery disease and undergoing coronary angiography. Routine blood investigation, ECG, Chest cardiograph, and 2D Echo test were performed. Results: A total 100 patients established that hs-CRP were elevated in all the patients irrespective of risk factor status. Also there was statistically significant difference between the levels of hs-CRP and angiographic extent of lesion. hs-CRP levels were also found to be higher in in patients with positive family history of CAD and elevated LDL-C, decreased HDL-C. Conclusion: measurement of hs-CRP should not be used as an alternative for but as an adjunct to major risk factors in assessing and thus better define the intensity of preventive therapies to be initiated
ABSTRACT
Background: Community acquired pneumonia (CAP) has been recognized as a common and potentially lethal condition nearly two centuries ago. CAP is a spectrum of diseases ranging from a simple febrile respiratory infection to a severe and fulminating illness leading to death. Aim: To obtain comprehensive insight into the mode of presentation, clinical, bacteriological and radiological profile of patients with community acquired pneumonia for the early detection of the disease. Materials and methods: A total 50 patients diagnosed as community acquired pneumonia as defined by MNR Medical College and Hospital were considered and analyzed individual clinical, radiological and microbial status for predetermination of disease. Results: Dyspnoea was significantly dominant in aged CAP patients (p< 0.001) and chest pain was frequent in younger CAP patients (p=0.090). Gram-positive cocci were observed in (70%) and gramnegative bacilli in 26% whereas, mixed cocci were found in 4%. In radiological examination, CAP associated with COPD was constituted 22%. Conclusion: Identification and determining the etiological and clinical patterns of Community Acquired Pneumonia helps in adoption of regionally optimized diagnostic and therapeutic approach.