ABSTRACT
Juliflorine, an antimicrobial and main alkaloid of Prosopis juliflora, has been studied for its pharmacokinetics and bioavailability in a single dose experiment conducted in rabbits and chick embryonated eggs. Bioactive juliflorine could not be detected in rabbit sera and also in various organs, such as heart, liver, brain, kidney, lungs and body tissues of the 12-14 days old chick embryonated eggs. On the contrary bentonite particles, coated with juliflorine, were detected mainly in heart and a few in kidney tissues of chick embryo. This shows that juliflorine has some affanity with heart tissue and little with the kidney tissue. This alkaloid probably reacts firmly with tissue and/or metabolizes quickly and looses its biological activity. On the other hand in vitro study shows that it precipitates at slightly alkaline pH or reacts with some serum component but retains some of its antibacterial activity