ABSTRACT
The results showed decreases in the percentage change of the mean body weight gain, absolute and relative kidney weight, and the number of nephron in both the right and left kidney of propranolol [P.] and /or verapamil [V.] treated rat groups. Moreover significant decrease were shown in serum Na, urinary K, and renal Na-K-ATPase activity while significant increase was illustrated in serum K and Ca; urinary Na and Ca; and serum urea and creatinine of the same groups. The changes were more obvious in the group treated with [P+V] in combination. Administration of calcium chloride [CaCl[2]] minimized these effects. Histopathological and histochemical examination revealed tubular epithelial degenerations in either P or V groups and accompanied by glomerular changes and interstitial nephritis. The group given combined P+V. The previous lesions were diminished after calcium supplementation. These results ensure the adverse effects of the combined use of these drugs on the kidney, and deduce that calcium supplementation may reduce these changes but does not prevent them completely