Correlation between eHealth literacy and physical fitness of college students / 中国学校卫生

Objective@#To understand the current situation and association of eHealth literacy with physical health of college students, so as to provide a basis for physical health improvement.@*Methods@#By using stratified random clustering sampling method, a total of 1 446 students from first to third year of college in four colleges and universities in Dongguan were selected for the eHealth literacy questionnaire and physical fitness test.@*Results@#The average eHealth literacy score of college students was(29.72±6.19), with a pass rate of 48.8%. The scores for each dimension were application ability (18.57±4.10), judgment ability (7.48± 1.67 ), and decision making ability (3.67±0.91). The differences in eHealth literacy scores among college students with different birthplaces, family upbringing and frequency of participation in outdoor sports were statistically significant( t/F=-2.44, 3.51, 10.19 , P <0.05). The mean score of physical fitness was (73.20±7.86), with a failure rate of 5.0%, a passing rate of 77.0%, a success rate of 17.1%, and an excellent rate of 0.8%. The differences in scores of physical fitness test varied significantly by gender, grade, and frequency of participation in outdoor sports( Z=-2.27, 8.75, 39.90, P <0.05). Pearson correlation analysis showed that eHealth literacy and the three dimensions of application ability, judgment ability, and decision making ability were positively correlated with total physical fitness test scores( r=0.17, 0.18, 0.16, 0.19, P <0.01). Multiple linear regression analysis showed that after adjusted for gender, grade, and frequency of participation in outdoor sports, eHealth literacy application ability, judgment ability, and decision making ability could significantly and positively affect physical fitness test score( β=0.13, 0.12, 0.12, P < 0.05 ).@*Conclusion@#Physical fitness of college students is associated with eHealth literacy,promotion of eHealth literacy among college students help improve physical health status.

Non-thermal Plasma Suppresses Bacterial Colonization on Skin Wound and Promotes Wound Healing in Mice / 华中科技大学学报（医学）（英德文版）

The present study evaluated the effect of non-thermal plasma on skin wound healing in BalB/c mice.Two 6-mm wounds along the both sides of the spine were created on the back of each mouse (n=80) by using a punch biopsy.The mice were assigned randomly into two groups,with 40animals in each group:a non-thermal plasma group in which the mice were treated with the non-thermal plasma; a control group in which the mice were left to heal naturally.Wound healing was evaluated on postoperative days (POD) 4,7,10 and 14 (n=5 per group in each POD) by percentage of wound closure.The mice was euthanized on POD 1,4,7,10,14,21,28 and 35 (n=1 in each POD).The wounds were removed,routinely fixed,paraffin-embedded,sectioned and HE-stained.A modified scoring system was used to evaluate the wounds.The results showed that acute inflammation peaked on POD 4 in non-thermal plasma group,earlier than in control group in which acute inflammation reached a peak on POD 7,and the acute inflammation scores were much lower in non-thermal group than in control group on POD7 (P＜0.05).The amount of granular tissue was greater on POD 4 and 7 in non-thermal group than in control group (P＜0.05).The re-epithelialization score and the neovasularization score were increased significantly in non-thermal group when compared with control group on POD 7 and 10 (P＜0.05 for all).The count of bacterial colonies was 103 CFU/mL on POD 4 and ＜20 CFU/mL on POD 7,significantly lower than that in control group (109 CFU/mL on POD 4 and ＞1012 CFU/mL on the POD 7) (P＜0.05).It was suggested that the non-thermal plasma facilitates the wound healing by suppressing bacterial colonization.

T2 mapping of articular cartilage in the healthy knee using a magnetic resonance segmentation / 中国医学科学院学报

<p><b>OBJECTIVE</b>To evaluate T2 mapping of the healthy knee articular cartilage in different subregions using a magnetic resonance segmentation.</p><p><b>METHODS</b>T2 mapping was performed to 77 healthy tibiofemoral cartilages, which were divided into group H1 ( <40 years old) and group H2 (≥ 40 years old). T2 values of cartilage IN 10 subregions based on the Whole-Organ Magnetic Resonance Imaging Score (WORMS) segmentation and body mass index (BMI) were calculated. T2 values of cartilage in 10 subregions were compared. The association between T2 value and BMI/age was analyzed. The intra- and inter-observer reproducibility of measurement was calculated.</p><p><b>RESULTS</b>The T2 values of all the subregions ranged 40. 3-53.5 ms. T2 values of group H2 were significantly higher than those in group H1 (P ≤ 0.032) except in posterior lateral femoral subregion. The inter-subregion differences within group were significant (P ≤ 0.001). The inter-gender differences were significant only in posterior medial tibial subregion of group H2 (P=0.048). No correlation of T2 values with BMI was found except in cetral lateral tibial subregion of group H2 (P=0.050, R=0.308). T2 values were correlated with age in anterior medial (P=0.004, R=-0.467) and anterior lateral P = 0.024, R=-0.375) tibial subregion of group H1 , and in all tibial subregion except anterior lateral tibial subregion of group H2 , and central medial femoral subregion of group H2 (P=0.004~0.015, R=0.376~0.437). The correlation coefficients for intra- and inter-observer of measurement showed good reproducibility (R>0.809, P ≤ 0.005).</p><p><b>CONCLUSION</b>T2 mapping of the healthy knee articular cartilage based on the WORMS segmentation can effectively reflect the changes and correlations of T2 values with risk factors by focusing on the functional weight-bearing subregions.</p>

Scoliosis on pulmonary function / 中国医学科学院学报

Scoliosis is a common disease in children that causes deformity of spine and thoracic cage. The deformity not only affects the appearance, but also leads to irreversible impairment of lung function and respiratory failure in severe cases. This systematic review on publications over past 50 years demonstrates that scoliosis impairs growth and development of lungs, limits chest wall movement, and results in restrictive ventilation defect and gas exchange dysfunction. Respiratory failure occurs primarily in early-onset scoliosis and/or during latter half of gestation. Surgery corrects deformity and may slow down its progression. However, invasive procedure itself impairs lung function. Non invasive procedures prevent the deterioration of lung function rather than promoting growth and development of lungs. As a consequence, reserve of pulmonary function is recommended when surgical intervention is considered.

T2 mapping of articular cartilage in knee osteoarthritis using a magnetic resonance staging / 中国医学科学院学报

<p><b>OBJECTIVE</b>To evaluate T2 mapping of articular cartilage in knee osteoarthritis (OA).</p><p><b>METHODS</b>Totally 38 healthy subjects (group H) and 53 OA patients received scoring with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)and underwent T2 mapping of tibiofemoral articular cartilages. The T2 values in 10 subregions of the cartilages were measured. Patients in the OA group were further divided into OA1 group and OA2 group using the modified Magnetic Resonance Recht Grading System. In OA group, the fat-suppressed three-dimensional fast spoiled gradient echo MRI was performed to obtain the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). The differences of T2 values among group H, group OA1, and group OA2 were compared. The correlation between T2 value and WORMS/WOMAC scores was analyzed. The intra- and inter-observer reproducibility of measurement was calculated.</p><p><b>RESULTS</b>The T2 values in all the subregions ranged 43.9-53.6ms in group H, 41.1-55.0 ms in group OA1, and 45.6-56.1ms in group OA2. T2 values in group OA2 were significantly higher in central medial femoral subregion, central medial, and lateral tibial subregions compared with group H, also significantly higher in central medial femoral subregion, anterior and central medial tibial subregions compared with group OA1 (P<0.05). T2 values were significantly correlated with WORMS scores (R=0.307-0.811, P<0.01) except in posterior lateral femoral subregion, but not with WOMAC scores. The correlation coefficients for intra- and inter-observer measurement showed good reproducibility (R>0.740, P<0.05) except in anterior lateral tibial subregion for inter-observer of measurement.</p><p><b>CONCLUSION</b>T2 mapping can differentiate the OA severity of knee cartilage using a magnetic resonance staging, and therefore can be a sensitive technique for monitoring the severity of OA.</p>

Spinal factors affecting pulmonary function in patients with scoliosis / 中国医学科学院学报

<p><b>OBJECTIVE</b>To investigate pulmonary function impairment and the spinal factors that may determine pulmonary function in patients with scoliosis.</p><p><b>METHODS</b>Seventy-eight patients with idiopathic scoliosis or congenital scoliosis and 78 age- and gender-matched healthy subjects were enrolled in this study. The radiographic parameters of spinal deformity were obtained from patients with scoliosis. Both two groups received pulmonary function tests.</p><p><b>RESULTS</b>Patients with scoliosis demonstrated a restrictive pattern of pulmonary function impairment with a proportional decrease in both forced expiratory volume in one second and forced vital capacity. Total lung capacity and functional residual capacity were reduced. Carbon monoxide diffusion capacity was decreased, while diffusion coefficient remained normal or slightly higher. Airway resistance and conductance were not affected. In addition, airway resistance and residual volume were found abnormal in patients with congenital scoliosis. Multiple linear regression analysis showed that three spinal factors including involved thoracic vertebrae, vertical height from C7 to S1, and Cobb angle were independently responsible for 40%-51% of total variances of forced vital capacity, forced expiratory volume in one second, total lung capacity, and functional residual capacity.</p><p><b>CONCLUSIONS</b>Patients with scoliosis have restrictive ventilation defects. More thoracic vertebrae involvement, lower vertical height, and larger Cobb angle are associated with severer impairment of lung volume.</p>

The Nongenomic Effects of Progesterone in Repressing iNOS Activation through P38MAPK Pathways in Gonococci-Infected Polymorphonuclear Leukocytes and the Clinical Significance / 华中科技大学学报（医学）（英德文版）

Progesterone has nongenomic effects on inducible nitric oxide synthase(iNOS),which is mediated by mitogen activated protein kinase(MAPK)pathways.This effect is supposed to have some potential association with asymptomatic gonococcal infections in women by immunological depression.In this study,polymorphonuclear leukocytes(PMNs)challenged by gonococci were used to study the nongenomic effects of progesterone.The activation of iNOS was assessed by measuring[3H]L-arginine converses to[3H]L-citruiline,and the activity of MAPK was detected by Western blot.It was found that the activity of iNOS and the yields of NO were enhanced significantly in gonococci-challenged PMNs compared with the controls(P<0.01).Progesterone could repress the activation of iNOS through P38MAPK pathway within PMNs(P<0.05),which could be blocked by SB203580(P<0.01),but not by actinomycin D(P>0.05).It was also found subsequently that in the serum specimens collected from gonococci-infected but asymptomatic women,the progesterone level was higher than that in women with severe symptoms(P<0.01).Moreover,the yield of NO had an inverse correlation with progester-one.With these results it suggested that the rapid nongenomic effects of progesterone may inhibit iNOS activation and NO yields mediated by P38MAPK pathways,which were supposed to be concerned with asymptomatic women infected with gonococci.

Typing of Neisseria gonorrhoeae Opa and NG-MAST Gene of 12 Pairs of Sexual Contact Gonorrhea Patients in China / 华中科技大学学报（医学）（英德文版）

To identify the genomic species of Neisseria gonorrhoeae, evaluate the difference between two molecular epidemiological methods and examine the relationship between sex partners and genotypes of bacteria, 24 strains of Neisseria gonorrhoeae isolated from the outpatients with gonorrhea were identified by using the Opa genotyping and NG-MAST genotyping and the relationship between genotypes and phenotypes was studied. Twenty-four strains of Neisseria gonorrhoeae fell into 10 ST genotypes by NG-MAST genotyping, whereas these strains were classified into 12 OT Opa genotypes by Opa genotyping. A new epidemic strain of ST genotype (217-86% homologisation 178) in China was identified. It is concluded that genotypes of each pair of strains from a pair of patient/sex partner besides 45/46 are the same, indicating that contagious infection take place between patient and the sex partner. Opa genotyping was more effective than NG-MAST genotyping in identifying the genomic species of Neisseria gonorrhoeae. ST genotype could be further classified into different Opa-types.