ABSTRACT
Background: It was to evaluate the association of serum levels of vitamin D in patients with congestive heart failure.Methods: The present study was conducted in the department of Medicine at Chattrapati Shivaji Subharti Hospital among 100 patients, aged 18 years and above diagnosed as congestive heart failure on the basis of clinical and echocardiographic evidence. Clinical manifestations looked for CHF were: Dyspnea, orthopnea, acute pulmonary edema, cerebral symptoms, cheyne-stokes respiration, cyanosis, sinus tachycardia, raised jugular venous pressure, congestive hepatomegaly and pedal edema. In the present study deficiency/ insufficiency of vitamin D was considered when the presence of levels of 25-hydroxyvitamin D was <30 ng/ml. Laboratory tests performed to diagnose congestive heart failure and serum vitamin D levels were complete blood count, KFT (urea, serum creatinine), serum electrolytes, ECG, chest X ray and echocardiogram. Data were tabulated and examined using the statistical package for Social Sciences Version 22.0.Results: When data was assessed for comparison in relation to NHYA grades and vitamin D levels, it was found to be statistically significant. The Mean±SD scores of serum urea (mg/dL) was found to be 44.7±56.4, 47.3±63.8 and 36.4± 18.3 in whole study sample, vitamin D levels <30 and vitamin D levels >30 respectively with statistically significant difference. The Mean±SD scores of CPK MB (IU/L) was found to be 33.1±20.8 and 18.6±13.3 among the subjects having vitamin D levels <30 and vitamin D levels >30 respectively with statistically significant difference.Conclusions: The results of the present study suggest that low levels of vitamin D may adversely affect the cardiovascular system.
ABSTRACT
Introduction: Metabolic syndrome (Metabolic syndrome)is a complex disorder with high socioeconomic cost that isconsidered a worldwide epidemic. Current research aimed tostudy serum testosterone levels in metabolic syndrome.Material and methods: The present study was ProspectiveObservational study carried out at CSS Hospital, SubhartiMedical College Meerut U.P. 100 patients of metabolicsyndrome were included in the study who fulfilled the IDFcriteria of metabolic syndrome these patients underwentgenral examination, anthropometry,systemic examination,bmi was calculated, different investigation (Fasting LipidProfile, Serum Testosterone Levels,HBA1C, blood sugarlevels). Descriptive analysis of the collected data was done.Correlation of serum testosterone with various componentsof metabolic syndrome was studied using SPSS software tocalculate the level of significanceResults: This study confirmed the high prevalence of lowtestosterone levels in male patients with metabolic syndrome.The total number of patients who had BMI of more than 35 kg/m2, were 18 and all those had low levels of testosterone whichis significant (p value<0.001). The total number of patientswho had triglyceride level of >150, were 80 and all those hadlow levels of testosterone which is significant (p value<0.001).The total number of patients with low testosterone levels inwhom HbA1C was more than 7.5%, were 68. Patients withnormal level of testosterone were 32 in whom HbA1C was6.5-7.5% which is significant (p value<0.001).Conclusion: This study confirmed the high prevalence of lowtestosterone levels in male patients with metabolic syndrome.Multiple associations and predictors of low testosterone levelswere identified by evaluating different demographic, clinicaland other variables.