ABSTRACT
Background: It was reported that intermittent fasting has several health benefits. Therefore, the present study aimed to assess the hemodynamic variations associated with Ramadan fasting among Saudi Stroke patients. Methodology: Information referring to 61 stroke patients were retrospectively retrieved from King Khalid hospital, Hail, Northern Saudi Arabia. Data relating to patients attended during the period from April 2019 to June 2019. The sample involved two months (Shaban and Ramadan) a full coverage sample. Results: Out of 61 study subjects, 26 patients were fasting during stroke happening and 35 patients were non-fasting. Out of the 61 patients, 35 (57.4%) were females and 26 (42.6%) were males. With the fasting month, hypertension was co-occurrence in 23/49 (47%) fasting patients, hence, it occurred in 26/49 (53%) among non-fasting patients, the risk of hypertension during Ramadan compared to nonfasting month; the relative risk (RR) and 95% confidence interval (95% CI): RR (95%CI)=1.1908 (0.9374 to 1.5128). Conclusion: Ramadan Fasting has some beneficial effects influencing stroke including incidence and severity reduction. Stroke associated hemodynamic variants, which were more apparent among women, were perceived to decline during fasting.
ABSTRACT
Objective: To use chorionic villi sampling [CVS] and amniocentesis to determine the genotyping of Gaucher Disease [GD] of fetuses of pregnant mothers who had a previous child affected by GD
Methods: The study was conducted between January 2009 and December 2012. It included 42 pregnant women that gave informed written consent. Thirty mothers presented early so they underwent CVS at 1012 weeks of pregnancy while 12 mothers presented later and underwent amniocentesis at 1416 weeks. Strip assay for the identification of Glucocerebrosidase [GBA] gene mutations in the samples of chrorionic villi and amniotic fluid was based on polymerase chain reaction [PCR] and reverse hybridization
Results: The age of the studied pregnant women ranged from 19 to 26 years. Consanguinitywas present in 38 cases. Eighteen women were pregnant in affected fetuses. The results of genotyping revealed 15 cases were homozygous L444P/L444P and one case homozygous [N370s/N370s] while two cases were heterogeneous [L444P/D409H]. Twenty-four pregnant women had carrier fetuses which were all heterozygous L444P
Conclusion: This study highlights the findings of an extended gene mutation examination for prenatal diagnosis of Guacher Disease. The study found out that the most common mutation was L444P/L444P