ABSTRACT
To evaluate cord blood erythropoietin as a predictor of peri-natal risk in correlation to other clinical, ultrasonographic and biochemical parameters. Prospective randomized study. Ain Shams maternity Hospital. 120 full term newborns and their mothers curing the period from November 1997 to November 1999. They were grouped: group I [20 cases as control], group II [100 cases as studied group]; IIa [24 pre-eclamptic patients], IIb [21 hypertensive patients], IIc [18 gestational diabetic patients], IId [13 diabetic patients], IIe [9 cases with low CTG = 6], IIf [8 cases with unexplained decreased placental blood flow], IIg [7 cases of maternal smoking]. All cases were subjected to full clinical, biochemical and ultrasonographic evaluation, blood gases [PO[2], PCO[2], and PH] and erythropoietin cord blood was measured in all cases. Erythropoietin level is highly significantly increased in all high risk subgroups [except group IIe] when compared to control group, cord erythropoietin had significant positive correlation. There is negative relation between erythropoietin level and neonatal birth weight. Non significant relation between erythropoietin level and abnormal heart rate pattern, meconium stained amniotic fluid and Apgar score.Cord erythropoietin is an excellent marker of chronic fetal hypoxia while blood gases [PO2, PCO2 and PH] are good marker of acute fetal hypoxia