ABSTRACT
The changes in AChE and MAO activities were studied in nine brain regions of albino rat following daily i.p. injection of two separate doses of atropline sulfate [0.8 or 1.6 mg/100 g body wt] for six days. Injection of either of the two doses provoked a general decrease of AChE in most of the brain areas studied. The amount of decrease was not the same at the different time intervals investigated. This decrease may be due to an interruption of brain cholinergic synapses which form a part of inhibitory mechanism controlling the activity of cholinergic neurones. The effect of atropine sulfate on MAO activity is variable from region to region which may be due to both the release of enzyme from the mitochondrial membrane and changes in its catalytic properties