ABSTRACT
Thirty cases of endometrial carcinoma and 10 control cases [normal endometrial tissue] were studied in this work. Two years follow-up for patients was performed in order to record the recurrence and metastatic cases. ER immunopositivity were detected in 80% of the carcinoma cases [24 out of the 30 cases] and 20% of the control cases [2 out of the 10 cases]. PR were expressed in 70% of the malignant cases and 10% of the control cases. Both receptors were detected in 68% of the same tumor cells and 10% of the control cells. Both receptors were markedly immunoexpressed in patients below 50 years and in premenopausa1 women. There was inverse relation between both receptors over expression and tumor grade and increased clinical stage, the relation was significant. No recurrence or metastasis was detected in these positive cases, through 2 years follow-up. Carcinoembryonic antigen [CEA] immunopositivity was detected in 63.3% of the carcinoma cases and none of the control cases. No relation was detected between CEA immunopositivity and age, menopausal state, tumor type or tumor differentiation. Marked immunoexpression was seen in stage III tumor. Three cases of recurrence were recorded in immunopositive CEA carcinoma cases. DNA ploidy was studied by image analyzer. Nine carcinoma cases were diploid [DNA index <1] and 21 were aneuploid [DNA index >1]. All control cases were diploid. Tumor aneuploidy was highly recorded in old age group [above 50 years] and in postmenopausal women. There was a direct relation between tumor aneuploidy and increased tumor grade and clinical stage. The relation was significant. No relation was detected between aneuploidy and different histological types