Peroxidative damage and cancer colon risk in animals fed repeatedly heated cotton seed oil

The present study was conducted experimentally to assess the potential health hazards of ingesting repeatedly heated frying oil. Ten male albino rats were fed rodent chow containing 20% [w/w] of either fresh or repeatedly heated oil for three months. Thiobarbituric acid reactive substance concentrations [TBARS] were significantly higher in repeatedly heated oil samples compared to fresh oil samples. Feeding rats with repeatedly heated oil resulted in significant increase in heptosomatic and nephrosomatic indices with significantly higher serum levels of alkaline phosphates activity and urea creatinine as compared to those fed with fresh oil indicating to nutritional hepatic and renal cellular impairment

effect of S-adenosyl-L-methionine on brain catecholamines in lead-intoxicated rats

Lead poisoning is still an occupational problem with several behavioral and neurological effects. The exact nature of lead neuropathy and encephalopathy is yet unknown. It was suggested that lead might cause an alteration in brain catecholamines because of the known correlation between hyperactivity and catecholaminergic function. S-Adenosyl-L-Methionine [SAME], which is now commercially available as a stable salt, was found beneficial in the treatment of lead poisoning. Results show that the noradrenergic mechanism is more susceptible to lead toxicity than the other mechanisms. Treatment of intoxicated rats with SAME was found to decrease these high levels of catecholamines. Histopathological examination of brain following lead intoxication reveals focal necrosis, focal neutrophilic infiltration with severe and apparent gliosis. These changes were the same in SAME-treated group

Treatment of lead poisoning by S-adenosyl-L-methionine

Lead poisoning remains a major public health problem. It induces many biochemical and histopathological changes that affect many organs. The effect of S-Adenosyl-L-Methionine [SAMe] administration on the management of lead toxicity was investigated. Rats with either acute or chronic lead intoxication were treated with S.C. injection of SAMe [30 mg/kg body weight] daily over a period of 2 days. The beneficial effects of SAMe were evaluated by a comparison between the treated and non-treated animals using different biochemical and histopathological paramenters. Results obtained from both acute and chronic poisoning were in similar pattern