ABSTRACT
To Assess the circulating Biochemical, Heamatological and Oxidative Stress Markers in Females using Contraceptives from Punjab, Pakistan. Study Design: Case Control Study Place and Duration of Study: This study was carried out at the Gynae Units of Jinnah Hospital Lahore from January, 201 1 to December 201 1. Materials and Methods: Two injectable contraceptives [Depo-Medroxyprogesterone and NorethisteroneEnantate] and Oral contraceptive pills [COCs] were administered in females of reproductive age, the oxidative and nitrosative stress biomarkers [Malondialdehyde, Superoxide Dismutase, Catalase, Nitic oxide and Glutathione] were analyzed in these subjects. Results: DMPA, NET-EN and COCs treatment could induce oxidative stress with a significant change in lipid profile and other biochemical markers thus affecting the normal biological system. These effects after prolonged use can generate pathological events leading to disease pattern. Conclusion: These biomarkers can become diagnostic tools to evaluate the health of a woman using these methods as preventive measure in there
ABSTRACT
Current study was conducted to determine the fluctuations of various circulating biomarkers including thyroid hormones, hepatic enzymes, oxidative stress markers as well as electrolytes in schizophrenics. Cross Sectional Study. This study was conducted at Psychiatric Clinic of Jinnah Hospital, Mental Hospital from Jan. 2013 to Oct. 2013. Seventy five acute schizophrenics and twenty five healthy individuals were selected for this study. Patients with chronic infections, diabetic history, liver disease or any other history of drugs including smoking and/or drinking alcohol were excluded from the study. Elevated levels of oxidative stress in the form of malondialdehyde [MDA] [7.8 +/- 2.71*] were observed in schizophrenics. Similarly raised levels of T3 [6.9 +/- 1.31*] and T4 [61.2 +/- 15.44*] were found in patients as compared to control. Electrolytes like Na, K, Ca and Mg showed alterations in the serum of both patients and control. All the circulating biochemical markers were statistically significant [P<0.05]. It is concluded that lipid peroxidation may has association with thyroid hormones and electrolytes. Moreover, alleviated concentration of anti-oxidant biomarkers like SOD, catalase and GSH may play a central role in schizophrenics and anti-oxidant therapy may be useful for the management of this psychiatric disorder