ABSTRACT
Objective: To find the prevalence of hypertriglyceridemia in ischemic and hemorrhagic strokes and to assess the risk factors associated with them
Methodology: This cross-sectional study was conducted in Medical OPD/ Emergency, PAF Hospital Mushaf, Sargodha over a period of six months from Nov-2010 to May-2011. All patients of either gender diagnosed as having stroke, with hyper dense or hypo dense area on CT scan brain and of age more than 30 years were included in the study. Patients on anti-hyperlipidemic drugs, with previous history of stroke, having blood disorders, like hemophilia and idiopathic thrombocytopenic purpura and, on warfarin therapy were excluded from the study
Results: 203 patients were enrolled in the study. Out of these 203 patients 138[68%] were males, 65 [32%] were females.127[62.6%] stroke patients had hypertriglyceridemia. In multivariate analysis, hypertriglyceridemia was found to be the only risk factor associated with ischemic stroke adjusting for all the other variables. It was found that patients with hypertriglyceridemia had 3.24 times higher odds of having ischemic stroke [P-value=0.017]
Conclusion: Hypertriglyceridemia was found in majority of the patients with stroke. Furthermore, it was found to be an independent risk factor of ischemic stroke
ABSTRACT
Objective: To evaluate the incidence of liver damage based on grading of necro-inflammatory and fibrotic changes on hepatic cytology in patients suffering chronically with hepatitis C, presenting with alanine transaminase levels in normal ranges
Methodology: A cross-sectional survey was accomplished at department of medicine, PAF Hospital Mushaf, Sargodha for six months of duration from April 2012 to October 2012. 100 cases were evaluated. Liver biopsy was done using large bore sure cut biopsy needle under all aseptic measures after ultrasound marking and sent in 10% formalin for histological studies of inflammation and necrosis. Liver damage was declared for patients having grade 1 or more activity on METAVIR scoring system
Results: Majority of the patients were between 31-40 years of age and lowest age was 20 years. Average age of the patients was 33.2+/-7.4 years. Out of 100 patients, 47 patients [47.0%] were male while remaining 53 patients [53.0%] were females Liver damage was found in 41.0% patients
Conclusion: Liver biopsy should be performed for a clear diagnosis in patients suffering from HCV with alanine transaminase level within the normal ranges. Patients may suffer advanced hepatic disease despite normal levels of hepatic enzymes
ABSTRACT
Objective:To determine the frequency of type II diabetic patients with hypertriglyceridemia
Materials and Methods:This was a cross sectional study carried out at medical unit, PAF Hospital Mushaf, Sarghoda from 19th January 2013 to 18th July 2013. A total of 200 patients of either gender having age >30 years with type II diabetes either controlled or uncontrolled for at least 5 years were enrolled in the study. Patients on anti-hyperlipidemic drug, with history of ischemic heart disease, nephrotic syndrome, hypothyroidism and type I diabetes mellitus were excluded from the study
Results: Mean [+/-SD] age of enrolled participants was 53.25 [+/-7.5] years. 86 [43%] were males and 114 [57%] were females. Mean [+/-SD] fasting blood sugar level was 135 [+/-23.04] mg/dl and random blood sugar was 205.62 [+/-31.87] mg/dl. Mean [+/-SD] duration of diabetes was 6.69 [+/-1.87] years. Out of 200 patients of type II diabetes, 102 [51%] had hypertriglyceridemia out of which majority [63.7%] of patients had uncontrolled diabetes
Conclusions:The frequency of type II diabetic patients with hypertriglyceridemia is found to be 51% with majority having uncontrolled diabetes