Persistent Intraocular Residue with the Use of Dexycu® in Cataract Extraction: A Case Series

Purpose: The objective of this article is to report 8 cases of persistent IOL residue associated with the use of Dexycu® in the context of cataract surgery and then to subsequently describe each patients clinical course.Observations and Presentation: Between 2020-2021, persistent residue was noted in 8 eyes of 7 patients who received Dexycu® implants after cataract surgery. The residue was identified an average of 1.63 months after surgery (range 0.20-4.23). A subsequent procedure removed the residue from the intraocular lens; the average time to the follow-up procedure after surgery was 4.71 months (range 1.90-11.20).Conclusions and Importance: The Bausch and Lomb intraocular lenses seem to be predisposed to a Dexycu® persistent opacification, however correlation does not equate with causation. This article documents cases of persistent IOL residue with the use of Dexycu® and the MX60 lenses and its toric varieties. Further evaluation is necessary to elucidate the mechanism and risk factors for this occurrence.

Review on the ecology and taxonomy of sessile rotifers (Rotifera) with special reference to Mexico

Aim: Review of the new research on medium- and large-sized rivers in China and its impact to develop more rational management strategies for medium- and large-sized rivers.Methodology: Papers on rivers-related research in China published over the past 15 years (2004–2018) were summarised through statistical analyses. The main topics, data sources and contributions were also summarised, and representative papers were presented to illustrate milestones and contributions. Results: The management strategies of medium- and large-sized rivers shifted remarkably from traditional agricultural utilisation of floods and water resources to ecological protection. Water resources and pollution, conservancy projects and flooding and droughts were the four most focused research areas. Interpretation: Chinese economy significantly contributed to the change in river management strategies over the last two decades.

Polycarpol in Unonopsis, Bocageopsis and Onychopetalum Amazonian species: chemosystematical implications and antimicrobial evaluation

Polycarpol, a recurrent lanostane-type triterpene in Annonaceae family, was confirmed by thin layer chromatography and mass spectrometry analysis in the aerial parts (twigs and trunk barks) of Unonopsis duckei R.E. Fr., U. floribunda Diels, U. rufescens (Baill.) R.E. Fr., U. stipitata Diels, Onychopetalum amazonicum R.E. Fr. and Bocageopsis pleiosperma Maas. Its chemotaxonomic significance was discussed for these three genera, as well for the Annonaceae family. In addition, the antimicrobial activity against several strains of microorganisms was evaluated for the first time for this compound, being observed significant antibacterial activity against Staphylococcus aureus (ATCC 6538), Staphylococcus epidermidis (ATCC 1228) and Escherichia coli (ATCC 10538 and ATCC 10799) with minimal inhibitory concentration values between 25 and 50 μg ml−1.

Factors associated with overweight and central adiposity in urban workers covered by the Workers Food Program of the Brazilian Amazon Region / Fatores associados ao sobrepeso e adiposidade central em trabalhadores urbanos assistidos pelo Programa de Alimentação do Trabalhador da região amazônica do Brasil

OBJECTIVE: To investigate factors associated with overweight and abdominal obesity in male and female workers. METHODS: This is a cross-sectional population-based study. A representative sample of 1,054 workers ranging from 18 to 74 years of age, selected among individuals covered by the Workers´ Food Program living in the Metropolitan region of Belém, Northern Brazil. Health-related behavior and anthropometry were assessed. Fasting blood samples were collected. RESULTS: Overweight prevalence was 38.0 percent among women and 50.4 percent among men. Among overweight subjects, there were 6.1 percent obese women and 10.7 percent obese men. Multivariate analysis was used to identify social behavior and clinical-biochemical factors associated with increased body adiposity (BMI > 25 kg/m² and increased waist circumference: > 80 cm for women and > 94 cm for men). Variables positively and significantly associated with overweight and abdominal obesity in men according to prevalence ratio (PR) values were: age (1.02), high family income (1.05), smoking (1.36), hypertension (systolic blood pressure, 1.41; diastolic blood pressure, 1.85) and hypertriglyceridemia (2.29). In women, the PR of increased body adiposity was associated with: age (1.02), alcohol intake (1.42), hypertriglyceridemia (1.44), diastolic blood pressure (1.65) and hyperglycemia (1.71). CONCLUSIONS: The association of overweight and abdominal obesity with social behavior variables should be corrected with preventive and educational measures. Furthermore, association of overweight and abdominal obesity with clinical and biochemical variables places the urban workers from the Amazon region assisted by the Workers´ Food Program at a possible risk for morbidity and mortality from increased body adiposity.

OBJETIVO: Investigar os fatores associados ao sobrepeso e a obesidade abdominal em trabalhadores de ambos os sexos. MÉTODO: Estudo transversal de base populacional, de uma amostra representativa de 1054 trabalhadores, com idade entre 18 e 74 anos, assistidos pelo Programa de Alimentação do Trabalhador na região metropolitana de Belém do Pará, na região norte do Brasil. Parâmetros relacionados à saúde e medidas antropométricas foram obtidas e amostra de sangue foram coletadas. RESULTADOS: A prevalência de sobrepeso foi de 38 por cento nas mulheres e 50,4 por cento nos homens. Dentre os indivíduos com sobrepeso, 6,1 por cento das mulheres eram obesas e 10,7 por cento dos homens tinham obesidade. Análise multivariada foi utilizada para identificar os fatores sociocomportamentais e clínico-bioquímicos associados com o aumento da adiposidade corporal (IMC > 25kg/m2 e circunferência de cintura > 80cm para mulheres e >94cm para homens). As variáveis e a razão de prevalência (PR) associadas ao sobrepeso e adiposidade abdominal nos homens foram: idade (1,02), renda familiar alta (1,05), fumo (1,36), hipertensão (pressão arterial sistólica 1,41 e pressão arterial diastólica 1,85) e hipertrigliceridemia (2,29). Nas mulheres as razões de chance para sobrepeso e adiposidade abdominal foram: idade (1,02), consumo de álcool (1,42), hipertrigliceridemia (1,44), pressão arterial diastólilca (1,65) e hiperglicemia (1,71). CONCLUSÃO: A associação do sobrepeso e obesidade abdominal com parâmetros sociocomportamentais devem ser corrigidos com medidas educativas e preventivas. Além disso, a associação de sobrepeso e obesidade abdominal com parâmetros clínicos e bioquímicos coloca os trabalhadores de Belém do Pará, assistidos pelo Programa de Alimentação do Trabalhador, em possível risco de morbidades e mortalidade precoce pelo aumento de adiposidade corporal.

First isolation of Cryptococcus gattii molecular type VGII and Cryptococcus neoformans molecular type VNI from environmental sources in the city of Belém, Pará, Brazil

Cryptococcus neoformans and Cryptococcus gattii are important agents of meningoencephalitis in humans in the city of Belém. This clinical data suggests that the region may be a highly endemic area for the pathogenic Cryptococcus species within the state of Pará (PA), Northern Brazil. Preliminary analysis of 11 environmental samples from the city of Belém showed two positive locations, including a hollow of a kassod tree (Senna siamea) colonized simultaneously by C. gattii molecular type VGII and C. neoformans molecular type VNI, and a birdcage in a commercial aviary positive for C. neoformans, molecular type VNI. This is the first evidence of an environmental occurrence of molecular types VNI and VGII in PA.

Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile / Prepatency, parasitemia and histological lesions in mice infected with two Trypanosoma cruzi populations isolated in Chile

Background:The great variability in the clinical presentation of Chagas disease may depend in part in the genetic variability of Trypanosoma cruzi populations. Aim: To compare prepatent period, parasitemia, mortality and histological lesions in mice infected with two populations of Trypanosoma cruzi isolated in Chile. Material and methods: Two Trypanosoma cruzi populations, isolated from Chilean Triatomides and genetically characterized by kinetoplast restriction fragment DNA profiles, were compared. Two groups of 40 Balb/c mice were studied. Each mouse was inoculated with 104 trypomastigotes, of the V-121 and sp COMB 2 Trypanosoma cruzi populations. The prepatent period, parasitemia, mortality and histopathological lesions, at different evolutionary stages of infection were registered during 32 days. Results: Prepatency and mortality were similar in both groups of mice. However, parasitemia was significantly greater in mice inoculated with V-121 than those inoculated with sp COMB 2. Amastigote pseudocysts and inflammation were present only in skeletal muscle and myocardium in both groups of mice. The intensity of tissue involvement was associated to the level of parasitemia, therefore it was greater in mice inoculated with V-121 population. Conclusions: V-121 population of Trypanosoma cruzi caused a greater parasitemia than COMB 2, in inoculated mice.

Flavonóides de Cissus verticillata e a atividade hipoglicemiante do chá de suas folhas

Cissus verticillata, a Vitaceae very used in the traditional medicine in Pará and Minas Gerais State - Brazil, was investigated in order to validate its indication for the hyperglycaemia control. The aqueous extract reduces the normal glycaemia of male white Wistar rats in about 19.5 percent. The hypoglycaemic effect of this extract could be related to the flavonoids found in the preparation. Luteolin, Kaempferol and Luteolin-3'-sulphate could be isolated from the aqueous extract after acid hydrolysis.

Embarazo tubario bilateral sucesivo.Caso clinico. / Bilateral successive tubal pregnancy. Clinical case

1. Se presenta el caso clinico de un embarazo tubario bilateral sucesivo: de tres y medio meses en una trompa y reciente en la opuesta. 2. Se comenta la rareza del caso. No hay descripcion de otro similar en la bibliografia nacional y en la extranjera solo hemos tenido acceso a la referencia de tres casos con cierta similitud, desde 1918. 3. Se analiza, ademas, la frecuencia global de embarazos ectopicos, la frecuencia de embarazo tubario unilateral y la escasa frecuencia de embarazos tubarios bilaterales simultaneos. 4. Se comentan algunos de los factores etiologicos de los embarazos tubarios, los que explicarian tanto la simultaneidad como la posibilidad de repeticion del cuadro en una misma paciente. 5. Se discuten algunos de los aspectos de la evolucion del embarazo tubario cronico. 6. Se analizam las tendencias clinicas actuales de la morbilidad y mortalidad de los embarazos ectopicos, las que no parecen haberse modificado a traves del tiempo. 7. Finalmente, se plantean algunos de los elementos que podrian contribuir a mejorar el porvenir gineco-obstetrico de estos casos