ABSTRACT
OBJECTIVE To investigate the distribution of the clinical isolated pathogenic bacteria and the drug resistance of common bacteria so as to provide evidence for clinical rational use of drugs.METHODS The data of 3848 strains isolated from clinical specimens during from Mar 2007 to Oct 2008 and their sensitivity to antibiotics were statistically analyzed by WHONET 5.3.RESULTS Total of 3848 strains were identified including 857 Gram-positive strains(22.3%),2270 Gram-negative strains(59.0%) and 721 fungal strains(18.7%).The top three pathogens were Candida albicans,Escherichia coli and Acinetobacter baumannii.The detection rate of MRSA,MRSE,and MRCNS was 51.7%,80.7%,and 83.6%,respectively.There were no vancomycin-resistant staphylococci and enterococci detected.The detection rate of ESBLs producing strains in E.coli,K.pneumoniae,and Proteus mirabilis was 56.6%,28.3% and 5.9% respectively.All kinds of Enterobacteriaceae are sensitive to imipenem,resistance rate ranged from 0 to 1.3%.A.baumannii and Pseudomonas aeruginosa had higher resistance rate to imipenem(38.3% and 19.0%,respectively).CONCLUSIONS The detection rate of fungi and non-fermentative bacteria increase and the resistance of the pathogens is increasing.We should pay more attention to the status,and enhance the resistance surveillance.