ABSTRACT
@#Histiocytic proliferation of the skin can be categorised into Langerhan and non-Langerhan types. Benign cephalic histiocytosis (BCH) is a rare cutaneous non-Langerhan histiocytosis typically affecting infants and young children. We report a case of benign cephalic histiocytosis in a boy who, at seven months of age, presented with multiple yellowish papular eruptions on his face. Over the course of 18 months, the lesion spread to his trunk and upper extremities, sparing the mucous membranes, palms and soles. There was no systemic involvement identified. A histopathologic examination of the skin lesion showed diffuse infiltration of histiocytes within the superficial dermis intermingled with scattered eosinophils and small lymphocytes. Immunohistochemical studies showed that the histiocytes were diffusely positive for CD68. Langerhan markers CD1a and S100 were negative. The correct distinction between BCH and other histiocytic proliferations of the skin is important because BCH has a self-limiting clinical course with a tendency of spontaneous remission.