ABSTRACT
Objective:To investigate the diagnostic value of MSCTP in Alzheimer's disease with sleep disorders as the primary manifestation.Methods:Seventy-six patients with Alzheimer's disease who had sleep disorders as the primary manifestation from January 2018 to December 2018 in the Seventh People's Hospital of Wenzhou were selected as study group, and 76 healthy subjects were selected as control group.Both two groups of subjects were diagnosed with MSCTP.The Pittsburgh sleep quality index(PQSI) score and the mini mental state examination (MMSE) score were compared between the two groups.The cerebral blood flow(CBF) was measured in the bilateral temporal lobe, frontal lobe, hippocampus and basal ganglia of the two groups.Results:The PQSI score of the study group[(9.42±0.60)points] was significantly higher than that of the control group[(2.87±0.17)points], the difference was statistically significant( t=11.379, P<0.05). The MMSE score of the study group[(16.54±1.19)points] was significantly lower than that of the control group[(27.49±0.82)points], the difference was statistically significant( t=9.637, P<0.05). The CBF of the left and right temporal lobe, frontal lobe, hippocampus and basal ganglia in the study group[left: (14.12±1.00)mL·min -1·100g -1, (18.40±1.29)mL·min -1·100g -1, (18.41±1.30) mL·min -1·100g -1, (31.90±11.41)mL·min -1·100g -1; right: (14.09±0.97)mL·min -1·100g -1, (18.42±1.02)mL·min -1·100g -1, (17.27±0.96)mL·min -1·100g -1, (15.48±6.28)mL·min -1·100g -1] were significantly lower than those in the control group[left: (19.30±1.12)mL·min -1·100g -1, (27.10±1.94)mL·min -1·100g -1, (27.13±1.42)mL·min -1·100g -1, (39.95±19.12)mL·min -1·100g -1; right: (19.32±1.11)mL·min -1·100g -1, (23.32±1.61)mL·min -1·100g -1, (22.18±1.00)mL·min -1·100g -1, (22.13±8.79)mL·min -1·100g -1], the differences were statistically significant( t=8.412, 8.469, 13.076, 4.763, 13.125, 5.183, 9.874, 7.376, all P<0.05). Conclusion:The sleep quality and cognitive ability of Alzheimer's disease patients with sleep disorders as the primary manifestation are poor, the diagnosis of MSCTP shows that CBF of patients are significantly reduced, which has certain value for clinical diagnosis.