ABSTRACT
Objective@#To explore the impact of stage recovery training on children with autism spectrum disorder, and to provide reference for the scientific and rational rehabilitation and recovery training plans.@*Methods@#A total of 59 children with autism spectrum disorder in Luzhou were recruited and randomly divided into control group, intervention group Ⅰ and intervention group Ⅱ for 4 stages of T1-T4 recovery training. Before and after the training, Autism Behavior Checklist(ABC) was used to assess child s sensation, language, motor, communication and self care ability.@*Results@#There was no significant difference in the overall score of the ABC among the three groups in T1 and T2 stages ( P >0.05), but there was significant difference in T3 and T4 stages ( F= 3.98, 5.09, P < 0.05), which showed the intervention group Ⅰ and Ⅱ were lower than the control group. In terms of dimensions, in addition to the insignificant difference in language scores ( P >0.05), there were significant differences in feeling, communication, movement, and self care scores ( P <0.05). Overall score of the ABC in intervention group I and group II was lower than the control group ( P <0.05). Compared with the control group, the overall scores of children in intervention Ⅰ and intervention Ⅱ were significant in both T3 and T4 stages ( P <0.05). Compared with T1 stage, there were no significant differences in the overall scores of children in the control group in T2 stage, T3 stage and T4 stage ( P >0.05), while significant difference was observed in the intervention group Ⅰ and group Ⅱ in T2-T4 stage ( P <0.05).@*Conclusion@#Stage recovery training might help to alleviate the overall symptoms of children with autism spectrum disorder in sensation, communication, motor development and self care behaviors. The stage recovery training focusing on physical exercise can effectively alleviate the physical function of the child, while those focusing on social interaction is more conducive to improving child s social ability.
ABSTRACT
ABSTRACT Introduction: Postoperative atrial fibrillation (POAF) and pericardial effusion are important factors affecting prognosis after cardiac surgery. Recently, it has been reported that posterior pericardiotomy (PP) can effectively prevent the occurrence of POAF and pericardial effusion. To validate these conclusions and guide clinical practice, we conducted a systematic review with meta-analysis. Methods: We searched multiple databases for manuscripts published before July 2022 on the use of PP to prevent POAF and pericardial effusion and included only randomized controlled trials. The main outcome was atrial fibrillation after coronary artery bypass grafting, and secondary outcomes were included. Results: This meta-analysis included 14 randomized controlled trials with a total of 2275 patients. Meta-analysis showed that the incidence of POAF after cardiac surgery in the PP group was significantly lower than that in the control group (risk ratio=0.48; 95% confidence interval=0.33~0.69; P<0.00001). PP effectively reduced postoperative pericardial effusion (risk ratio=0.34, 95% confidence interval=0.21-0.55; P<0.00001). Conclusion: PP has shown good results in preventing POAF, pericardial effusion, and other complications, which indicates that PP is a safe and effective surgical method, but attention still needs to be paid to the potential risk of coagulation dysfunction caused by PP.
ABSTRACT
Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd tolerance in Morchella spongiola. 7444 differentially expressed genes (DEGs) were identified by cultivating M. spongiola in media containing 0.15, 0.90, or 1.50 mg/L Cd2+ . The DEGs were divided into six sub-clusters based on their global expression profiles. GO enrichment analysis indicated that numerous DEGs were associated with catalytic activity, cell cycle control, and the ribosome. KEGG enrichment analysis showed that the main pathways under Cd stress were MAPK signaling, oxidative phosphorylation, pyruvate metabolism, and propanoate metabolism. In addition, several DEGs encoding ion transporters, enzymaticon-enzymatic antioxidants, and transcription factors were identified. Based on these results, a preliminary gene regulatory network was firstly proposed to illustrate the molecular mechanisms of Cd detoxification in M. spongiola. These results provide valuable insights into the Cd tolerance mechanism of M. spongiola and constitute a robust foundation for further studies on detoxification mechanisms in macrofungi that could potentially lead to the development of new and improved fungal bioremediation strategies.
ABSTRACT
Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd tolerance in Morchella spongiola. 7444 differentially expressed genes (DEGs) were identified by cultivating M. spongiola in media containing 0.15, 0.90, or 1.50 mg/L Cd2+ . The DEGs were divided into six sub-clusters based on their global expression profiles. GO enrichment analysis indicated that numerous DEGs were associated with catalytic activity, cell cycle control, and the ribosome. KEGG enrichment analysis showed that the main pathways under Cd stress were MAPK signaling, oxidative phosphorylation, pyruvate metabolism, and propanoate metabolism. In addition, several DEGs encoding ion transporters, enzymaticon-enzymatic antioxidants, and transcription factors were identified. Based on these results, a preliminary gene regulatory network was firstly proposed to illustrate the molecular mechanisms of Cd detoxification in M. spongiola. These results provide valuable insights into the Cd tolerance mechanism of M. spongiola and constitute a robust foundation for further studies on detoxification mechanisms in macrofungi that could potentially lead to the development of new and improved fungal bioremediation strategies.