ABSTRACT
Background: Human cytomegalovirus (CMV) infection is the most common cause of perinatal viral infection. congenital CMV infection can produce varying degrees of neurodevelopmental disabilities. Aims and objectives were to study the fetomaternal outcome in CMV-Specific IgM antibodies.Methods: The study was prospective for a period of one and a half year. Hundred high risk patients with hundred controls were screened for CMV serology IgM. Maternal & fetal outcomes were noted.Results: Out of 100 cases in study group 27(27%) were positive for CMV IgM while in control group 6(6%) were positive(p<0.05). Primary CMV infection in mothers led to abortion in 2(7.4%) patients, pre-term labour in 5(18.5%), Postpartum hemorrhage in 6 (22.2%), fetal distress in 11(40.7%) while 37% had uneventful outcome. Among CMV positive cases 48.1% were born term live, 6(22.2%) were preterm, 1(3.7%) had IUD, Intrauterine growth restriction in 10 (37%), 6(22.2%) with congenital defect and 4(14.8%) with neonatal manifestations.Conclusions: CMV remains a significant public health concern. Education of young women in our community regarding hygienic and behavioral approaches that can help prevent CMV transmission is mandatory.
ABSTRACT
Introduction: Prevalence of viral infections in high riskpregnancies has not been studied so far in our population.Current research aimed to study the prevalence of viralinfections in high risk pregnancies.Material and methods: The Study was prospective fora period of one and a half year. Hundred high risk patientswith hundred controls were studied. The viral infectionsstudied included Rubella, Herpes Simplex Type 1 and Type 2,Cytomegalovirus (CMV), HBsAg, HCV, HIV-1 and 2Results: The mean age of the women in the study group was25.2+4 years and in the controls was 25.2+4 years Out of100 cases studied 29% were positive for CMV, vs 6% controlgroup (p < 0.05), 19% were positive for Rubella IgM, vs 1% incontrols. 21% cases were positive for HSV-1/ HSV-2 IgM, vs7% in controls, 5% were positive for HbsAg, vs nil in controls.7% were positive for HEV IgM, vs nil in controls. No case ofHCV IgM was found in study or control group. One case ofHIV IgM was found in study group and none in control group.Conclusion: The seroprevalence of viral infections issignificantly higher in high risk pregnancies as compared tocontrols. CMV infection was the most prevalent viral infectionin our studied population.