ABSTRACT
Diabetes is a common clinical metabolic disease, which can affect cardiovacular, cerebrovascular, eye, kidney and other organs, among which the clinical manifestations of diabetes-associated cognitive decline are not obvious and difficult to diagnose. 18F-FDG PET/CT has the ability to early identify metabolic changes and is widely used to diagnose neurological diseases, also can be used to evaluate abnormal brain glucose metabolism in diabetic patients. Neurons and astrocytes are closely related to brain glucose metabolism, and abnormal changes of cell number, function and metabolic activity may lead to cognitive decline in diabetes. The effects of abnormal changes of neuronal and astrocytes under hyperglycemia on cerebral glucose metabolism were reviewed, and the causes of brain glucose metabolism changed in diabetic were analyzed in this article, in order to provide theoretical basis for diagnosing diabetes-related neurological diseases.