ABSTRACT
Oral cancer is usually preceded by oral potentially malignant disorders (OPMDs) and early detection can downstage the disease. The majority of OPMDs are asymptomatic in early stages and can be detected on routine oral examination. Though only a proportion of OPMDs may transform to oral squamous cell carcinoma (OSCC), they may serve as a surrogate clinical lesion to identify individuals at risk of developing OSCC. Currently, there is a scarcity of scientific evidence on specific interventions and management of OPMDs and there is no consensus regarding their management. A consensus meeting with a panel of experts was convened to frame guidelines for clinical practices and recommendations for management strategies for OPMDs. A review of literature from medical databases was conducted to provide the best possible evidence and provide recommendations in management of OPMDs
ABSTRACT
There have been many attempts to establish biomarkers in order to determine the susceptibility of some normal human tissues to undergo malignant change. However, definitive markers for oral squamous cell carcinoma have not been yet achieved. Amongst some of the most promising molecular biomarkers, there is a respectful amount of literature produced on p53, both in human tissue fluids and in biopsies of potentially malignant lesions, 3p gene deletions, and, most recently, image-based ploidy analysis of tissue specimens.. In spite of the experimental character and speculative results of all those novel techniques, the image-based ploidy analysis appears to be the most sensitive and reliable method to predict malignant transformation in potentially malignant lesions of the oral mucosa