ABSTRACT
Objective :To explore levels of cystatin C (CysC) ,N terminal pro brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in patients with acute heart failure (AHF) and diagnostic value of their combined de-tection .Methods :A total of 61 AHF patients treated in our hospital from Feb 2014 to Feb 2016 were selected ,in-cluding 21 cases of NYHA class II ,20 cases of class III and 20 cases of class IV .Another 61 healthy subjects under-going physical examination were treated as healthy control group during the same period .Plasma levels of CysC , NT-proBNP and cTnT were measured and compared between two groups and among different cardiac function class group .Predictive value of single and combined detection of CysC ,NT-proBNP and cTnT for AHF and its prognosis were compared .Results : Compared with healthy control group ,there were significant rise in plasma levels of CysC [(0.89 ± 0.12) mg/L vs.(1.64 ± 0.61) mg/L] ,NT-proBNP [(186.24 ± 15.35) ng/L vs.(2562.44 ± 69.67) ng/L] and cTnT [ (0.08 ± 0.04) μg/L vs.(0.32 ± 0.31) μg/L] in AHF group ,P＝0.001 all.Compared with NYHA class II group ,there were significant rise in plasma levels of CysC [ (1.23 ± 0.47) mg/L vs.(1.73 ± 0.58) mg/L vs.(2.11 ± 0.62) mg/L] ,NT-proBNP [ (867.45 ± 48.91) ng/L vs.(1868.24 ± 79.70) ng/L vs.(3786.56 ± 89.94) ng/L] and cTnT [ (0.25 ± 0.08) μg/L vs .(0.39 ± 0.24) μg/L vs.(0.49 ± 0.37) μg/L] in class III group and class IV group ,and plasma NT-proBNP level of class IV group was significantly higher than that of class III group ,P＜0.05 or ＜0.01. Compared with single detection of CysC ,NT-proBNP and cTnT ,there were significant rise in predictive positive rates of AHF (49.18%,50.82%,54.10% vs.90.16%) ,malignant arrhythmia (44.00%, 48.00%,48.00% vs .80.00%) and heart failure aggravation (50.00%,44.44%,38.89% vs.83.33%) of triple detection ,P＜0.05 or ＜0.01. Conclusion :Combined detection of CysC ,NT-proBNP and cTnT possesses high eval-uation and predictive value for AHF risk and prognosis ,which is worth extending .