ABSTRACT
·Retinal neovascular disease is not an independent eye disease,which is more common seen in many other eye diseases spontaneously and cause serious damage to vision, such as retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, retinal central venous obstruction and retina venous inflammation, which present retinal neovascularization. The loss of normal blood vessels structure and function, causing pathological bleeding,oozing,edema and retinal detachment and other pathological changes, they are the main reason for loss of vision, which has become a worldwide blindness disease. At present, the main treatment for the disease include of laser occlusion, vitrectomy, repeated vitreous cavity injection of anti-vascular endothelial growth factor, those treatment has significant curative effect, but cannot prevent relapse of the disease. There is still no long-term effective treatment method nowadays. The emergence of stem cell therapy has provided potential alternative therapies. In this review, the latest application of bone marrow mesenchymal stem cells (BMSCs) in retinal neovascular disease will be discussed and present its migration advantages and promising clinical application prospects.