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OBJECTIVES@#To compare the clinical efficacy and safety of acupuncture and sodium hyaluronate eye drop in the treatment of aqueous deficiency dry eye.@*METHODS@#A total of 60 patients (120 eyes) with aqueous deficiency dry eye were randomly divided into an observation group (30 cases, 1 case dropped out) and a control group (30 cases, 1 case dropped out). In the control group, sodium hyaluronate eye drop were used, one drop at a time, 4 times a day, for 14 consecutive days. In the observation group, acupuncture was applied at bilateral Shangjingming (Extra), Cuanzhu (BL 2), Sizhukong (TE 23), Taiyang (EX-HN 5), and Tongziliao (GB 1) , once a day, treatment for 6 days with the interval of 1 day was required, for 14 consecutive days. The tear meniscus height (TMH), Schirmer Ⅰ test (SⅠT), ocular surface disease index (OSDI) score, non-invasive tear break-up time (NIBUT), and corneal fluorescein sodium staining (FLS) score were compared between the two groups before and after treatment, and the safety of the treatment of the two groups was observed.@*RESULTS@#Compared with those before treatment, after treatment, TMH, SⅠT and NIBUT were increased (P<0.01, P<0.05), and FLS scores were decreased (P<0.01) in the two groups; the score of OSDI was reduced (P<0.01) in the observation group. After treatment, in the observation group, TMH and SⅠT were higher than those in the control group (P<0.01), and the score of OSDI was lower than that in the control group (P<0.01). No adverse reactions and adverse events were observed in the two groups.@*CONCLUSIONS@#Acupuncture and sodium hyaluronate eye drop can both effectively treat aqueous deficiency dry eye, acupuncture has obvious advantages in improving TMH and basic tear secretion, and reducing the subjective symptoms of patients. Acupuncture for dry eye is safe.
Subject(s)
Humans , Hyaluronic Acid , Acupuncture Therapy , Dry Eye Syndromes/therapy , Eye , Tears , Ophthalmic Solutions , FluoresceinABSTRACT
AIM:To estimate the correlation between diabetic duration,blood glucose levels,plasma C-peptide and dry eye,and the risk factors for dry eye in patients with type 2 diabetes mellitus(T2 DM)METHODS:The clinical data of 51 patients (102 eyes) with type 2 diabetes diagnosed by the Department of Endocrinology,Jiangsu Provincial Hospital of Traditional Chinese Medicine was collected,in that 44 cases (88 eyes) of patients diagnosed with dry eye.Those patients were detected for the levels of glycosylated hemoglobin A1 c(HbA1 c),fasting blood-glucose (FBG),postprandial 2h blood-glucose (2h PBG),fasting plasma C-peptide and insulin,1h C-peptide and insulin.Corneal fluorescein staining(FL),tear break-up time(BUT) and Schirmer Ⅰ test (S Ⅰ t) were collected from all subjects.Compared biochemistry index and ocular surface index.The multiple Logistic regression was used to analyze the risk factors for dry eye in patients with r2DM.RESULTS:There was no significant differences between the patients with different diabetic duration,on BUT,S Ⅰ t,winking frequency,vision,FL and the scores of dry eye symptoms (P ＞ 0.05).HbA1c was significantly correlated with FL (P ＜ 0.05).There were significant differences in FL among patients with HbA1c in 8.1％ to 11.8％ (P＜0.01).FBG was significantly correlated with FL and winking frequency (P＜ 0.05).The 2h PBG was significantly correlated with tear secretion and vision (P＜0.05).Plasma C-peptide was significantly correlated with BUT (P＜0.05).There were significant differences in BUT among patients with 1h C-peptide in 3.3-5.5ng/mL(P＜0.05).FBG and plasma C-peptide in T2DM patients were risk factors for occurrence of dry eye(P＜0.05).CONCLUSION:Poor function of insulin secretion and poor control of blood glucose in T2DM patients are risk factors for dry eye.Both of them can decline tear film stability.High blood glucose levels easily lead to decrease of tear secretion,vision and corneal epithelial defect.
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?Dry eye is a common eye disease around the world, which has highly incidence. Although there are many treatment measures for dry eye, the clinical effect is not satisfactory. There is a close relationship between inflammation and dry eye, so the researchers pay more attention on anti -inflammatory therapy, such as fluorometholone. To explore the effect of anti -inflammatory medicine on dry eye, put forward the problems and shortcomings as well, lay the foundation for further study, and provide a strong theoretical basis for the clinical use of anti-inflammatory drugs in the treatment of dry eye, the author summarizes the clinical and experimental research progress of fluorometholone on dry eye in China and abroad.
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<p><b>OBJECTIVE</b>To observed the clinical efficacy on dry eye syndrome treated with acupuncture on the acupoints around the eyes.</p><p><b>METHODS</b>Fifty-six cases of dry eye syndrome were divided into two groups, acupuncture group and western medicine group, 28 cases in each one. In acupuncture group, acupuncture was applied to Jingming (BL 1), Cuanzhu (BL 2), Sizhukong (TE 23), Tongziliao (GB 1), etc. In western medicine group, the topical artificial tear eye drops were administered. The corneal fluorescein staining, breaking-up time (BUT), tear volume and the symptom score were observed before and after treatment in two groups.</p><p><b>RESULTS</b>In comparison before and after treatment in acupuncture group, the statistical significant difference presented in BUT, tear volume and the symptom score (all P < 0.01). In comparison before and after treatment in western medicine group, the statistical significant difference presented in corneal staining, BUT and the symptom score (P < 0.01). The improvements in BUT, tear volume and the symptom score in acupuncture group were superior to those in western medicine group (P < 0.01).</p><p><b>CONCLUSION</b>Acupuncture on the acupoints around the eyes achieves a quite good efficacy on dry eye syndrome.</p>