Clinical randomized controlled study on acupuncture for treatment of peripheral neuropathy induced by chemotherapeutic drugs / 中国针灸

<p><b>OBJECTIVE</b>To seek the effective treatment for peripheral neuropathy induced by chemotherapeutic drugs.</p><p><b>METHODS</b>Sixty-four cases of peripheral neuropathy induced by Paclitaxel or Oxaliplatin were randomly divided into an acupuncture group and a medication group, 32 cases in each group. The acupuncture group was treated with therapeutic principle of dredging meridians and collaterals, tonifying qi and eliminating blood stasis, supplementing liver and kidney, nourishing blood and tendon. Hegu (LI 4), Taichong (LR 3), Zusanli (ST 36), Qihai (CV 6) and Quchi (LI 11) etc. were selected. The medication group was treated with intramuscular injection of Cobamamide. The neurotoxicity of two groups was compared with questionnaire of peripheral neuropathy induced by chemotherapeutic drugs before and after treatment.</p><p><b>RESULTS</b>The total effective rate for sensory nerve disorder of acupuncture group was 66.7% (20/30), which was superior to that of 40.0% (12/30) in medication group (P < 0.05).</p><p><b>CONCLUSION</b>Acupuncture is more effective than Cobamamide for treatment of peripheral neuropathy induced by chemotherapeutic drugs, especially for moderate and severe sensory nerve disorder induced by paclitaxel.</p>

Progress on the treatment of chemotherapy-induced peripheral neuropathy by Chinese and Western medicine / 中国中西医结合杂志

Among all the adverse reactions of anti-tumor drugs, the incidence of chemotherapy-induced peripheral neuropathy elevated gradually in recent years, but no trustworthy treatment by Chinese and Western medicine for it has been found so far. The related clinical and experimental reports published in the latest 10 years were reviewed in this paper.