ABSTRACT
Objective:To explore the changes of serum zinc-2 glycoprotein (ZAG) levels in patients with polycystic ovary syndrome (PCOS) with metabolic indicators, and to seek the correlation between metabolic disorders and ZAG in patients with PCOS, so as to provide a basis for the diagnosis and treatment of metabolic disorders in patients with PCOS.Methods:A total of 200 Han PCOS patients admitted to Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine (Futian) from January 2017 to June 2018 were selected as the observation group, and divided into the group A (BMI ≥ 25kg/m 2) and the group B (BMI <25kg/m 2) according to body mass index(BMI). Meanwhile, 100 healthy Han women who came to the hospital for physical examination during this period were selected as the control group.ZAG, fasting blood glucose (FPG), fasting insulin (FINS), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured, and the differences among the three groups were compared.After weight control, group A reviewed the above indicators and compared the differences of these indicators before and after weight control. Results:In group A, the FPG, FINS, HOMA-IR, TC, TG, HDL, LDL and ZAG were (5.92±0.51)mmol/L, (19.94±3.15)mIU/L, (5.29±1.19), (5.59±0.49)mmol/L, (2.03±0.35)mmol/L, (0.72±0.21)mmol/L, (3.05±0.43)mmol/L, (35.80±8.12)ng/mL, respectively, which in group B were (5.38±0.62)mmol/L, (15.67±4.59)mIU/L, (3.84±1.45), (4.61±0.65)mmol/L, (1.49±0.35)mmol/L, (1.24±0.40)mmol/L, (2.61±0.40)mmol/L, (45.22±10.27)ng/mL, respectively, which in the control group were (4.77±0.53)mmol/L, (11.66±3.23)mIU/L, (2.52±0.95), (4.59±0.53)mmol/L, (1.39±0.26)mmol/L, (1.40±0.31)mmol/L, (2.50±0.35)mmol/L, (59.15±8.90)ng/mL, respectively, and the differences were statistically significant between group A and group B, between group A and control group, and between group B and control group( F=36.81, 41.04, 44.05, 33.65, 38.61, 39.25, 18.45, 56.88, all P<0.01). After weight control, the FPG, FINS, HOMA-IR, TC, TG, HDL, LDL and ZAG in group A were (5.27±0.54)mmol/L, (15.67±3.16)mIU/L, (3.72±1.06), (4.98±0.45)mmol/L, (1.62±0.30)mmol/L, (1.03±0.25)mmol/L, (2.82±0.43)mmol/L, (43.59±8.20)ng/mL, respectively, and the differences were statistically significant in group A before and after weight control ( t=15.26, 15.67, 17.70, 11.04, 17.61, -9.61, 22.83, -13.79, all P<0.01). The serum ZAG was positively correlated with HDL ( r=0.628, P<0.01), and negatively correlated with BMI ( r=-0.685, P<0.01), HOMA-IR ( r=-0.729, P<0.01), and TC ( r=-0.579, P<0.01). Conclusion:ZAG value is reducedin PCOS patients, with lower level in obesity group, and is positively correlated with HDL, negatively correlated with BMI, HOMA-IR, TC.The metabolism in patients with PCOS can be reflected by ZAG, which has a certain value in diagnosis and treatment of PCOS patients with metabolic disorder, and provides theory basis for further study of the metabolic disorder of PCOS.
ABSTRACT
Objective To compare vein graft quality and patency between the segmental incision and the open saphenous vein harvesting in coronary artery bypass grafting. Methods The data of patients underwent CABG in the First Affiliated Hospital of Wenzhou Medical University from January 2013 to December 2015 were retrospectively analyzed. The patients were devided into 2 groups,which is 99 open and 114 sagmental incision,by the way of harvesting. The operative risk factors,harvesting time and length of venous grafts,as well as the inci-sion complications were compared between the above two groups. One year after operation,the vein graft patency was detected by the coronary artery CTA. Results No significant differences in the risk factors of incision compli-cations were observed between the two groups,but the incidence of various incision complications was significantly reduced in the segmental incision group(P < 0.05). No significant difference in patency rate of venous grafts was observed between two groups at 1 years post?operation. Conclusion Segmental incision saphenous vein harvesting was safe and feasible,which can decrease the incision complications without obvious effect on postoperative patency.
ABSTRACT
Objective To compare vein graft quality and patency between the segmental incision and the open saphenous vein harvesting in coronary artery bypass grafting. Methods The data of patients underwent CABG in the First Affiliated Hospital of Wenzhou Medical University from January 2013 to December 2015 were retrospectively analyzed. The patients were devided into 2 groups,which is 99 open and 114 sagmental incision,by the way of harvesting. The operative risk factors,harvesting time and length of venous grafts,as well as the inci-sion complications were compared between the above two groups. One year after operation,the vein graft patency was detected by the coronary artery CTA. Results No significant differences in the risk factors of incision compli-cations were observed between the two groups,but the incidence of various incision complications was significantly reduced in the segmental incision group(P < 0.05). No significant difference in patency rate of venous grafts was observed between two groups at 1 years post?operation. Conclusion Segmental incision saphenous vein harvesting was safe and feasible,which can decrease the incision complications without obvious effect on postoperative patency.