Relationship between obesity and insomnia among adults / 预防医学

Objective@#To investigate the association between obesity and insomnia among adults, so as to provide insights into obesity control and sleep health improvements among adult populations. @*Methods@#Sixteen communities were randomly sampled from Longgang District, Shenzhen City using a multistage cluster sampling method, and permanent residents at ages of 18 years and older living in these communities were recruited as study subjects. Subjects' gender, age, educational level and marital status were collected using a self-designed questionnaire, and the body mass index ( BMI) was calculated. The sleep quality was evaluated using the Insomnia Severity Index ( ISI ), and the correlation between obesity and insomnia was evaluated using a multivariable logistic regression model.@*Results@#A total of 10 434 questionnaires were allocated, and 9 425 valid questionnaires were recovered, with an effective recovery rate of 90.33%. The respondents included 3 448 men ( 36.58% ) and 5 977 women ( 63.42% ), and 6 940 respondents ( 73.63% ) were at ages of 18 to 44 years. There were 778 respondents with underweight ( 8.25% ), 5 522 with normal weight ( 58.59% ), 2 209 with overweight ( 23.44% ) and 916 with obesity ( 9.72% ). Among all respondents, 1 149 respondents were detected with insomnia, with a detection rate of 12.19%, including 839 subjects with mild insomnia ( 8.90% ), 247 subjects moderate insomnia ( 2.62% ) and 63 subjects with severe insomnia ( 0.67% ). Multivariable logistic regression analysis showed a statistically significant correlation between obesity and insomnia ( OR=2.179, 95%CI: 1.824-2.603 ).@*Conclusions@#There is a significant correlation between obesity and insomnia. Body weight management and sleep health education shall be intensified among adults.

Design of Portable EEG and Blood Oxygen Synchronous Acquisition System / 中国医疗器械杂志

In order to obtain comprehensive brain activity information conveniently in real time, this study designs a portable EEG and blood oxygen synchronous acquisition system for real-time monitoring of brain functional activities. The EEG electrodes filter and amplify the detected EEG signals, and send them to the microprocessor via Bluetooth to analyze the EEG data; the photoelectric probe converts the optical signals into electrical signals, which are amplified and separated, filtered, and AD converted, calculates the brain's oxygenation and blood-red protein (ΔHbO

Design of Paravertebral Muscle Monitoring System Based on Surface Electromyography / 中国医疗器械杂志

In order to diagnose and evaluate the human spinal lesions through the paravertebral muscles, a paravertebral muscle monitoring system based on surface EMG signals was designed. The system used surface mount electrodes to obtain the surface myoelectric signal (sEMG) of paravertebral muscle. The signal was filtered and amplified by the conditioning circuit. The signal was collected by the microcontroller NRF52832 and was sent to the mobile APP. After the signal was preprocessed by the wavelet threshold denoising algorithm in APP, the time and frequency characteristics of the sEMG signal reflecting the functional state of the muscle were extracted. The calculated characteristic parameters was displayed in real time in the application interface. The experimental results show that the system meets the design requirements in analog signal acquisition, digital processing of signals and calculation of characteristic parameters. The system has certain application value.

Abnormal expression of proto-oncogene YES-associated protein in gastric cancer tissues in the elderly and its correlation with the poor prognosis / 中华老年医学杂志

Objective To investigate the abnormal expression of proto-oncogene YES-associated protein (YAP) in gastric cancer tissues in the elderly and its correlation with poor prognosis.Methods Clinical data of 80 elderly patients with gastric cancer treated in our hospital from March 2011 to October 2014 were statistically analyzed.Results The positive expression rate of YAP was significantly higher in gastric carcinoma than in adjacent tissues [71.3％ (57/80) vs.13.8％ (11/80),P＜0.05].The positive expression of YAP were significantly associated gastric tumor size,tumor stage,invasion depth and lymph node metastasis (all P＜0.05),but had no correlation with tumor differentiation (P＞0.05).The 5-year survival rate was significantly lower in patients with YAP-positive expression than in patients with YAP-negative expression (P ＜ 0.05),but the differences in 1-year,3-year survival rates were not significant between the two groups (all P＞0.05)The YAP expression,tumor stage,lymph node metastasis were significantly associated with the prognosis of gastric cancer in patients (all P＜0.05).Conclusions YAP-positive expression rate is significantly higher in gastric cancer tissues than in adjacent tissues in the elderly,which indicates poor prognosis of patients with gastric cancer.

Comparison of effects of the different dosage MK-801 on recognition memory in rats / 中华行为医学与脑科学杂志

Objective To observe the behavioral effects of acute administration of dizocilpine (MK-801) in rats,and to determine an appropriate doses of the drug to mimicking memory deficits of schizophrenia.Methods 192 rats were randomly divided into model groups and control group,and given different doses of MK-801 or saline.Locomotor activity,pre-pulse inhibition (PPI) test and novel object recognition test were studied respectively.Results The spontaneous activity increased in a dose-dependent manner after the treatment of MK-801.The total distances of locomotor activity in 0.3 mg/kg group((127.04 ± 32.35) m) exhibited a significant difference compared with control group((35.34 ± 12.81) m,P ＜ 0.05).MK-801 decreased PPI in dose-dependent manner(P ＜ 0.01).MK-801 0.1 mg/kg((103.45 ± 68.04) ％) and 0.3 mg/kg ((41.55 ± 62.93) ％) groups showed significant differences compared to control group ((200.39 ± 30.97) ％) in PPI.The discrimination index of 0.03 mg/kg group((15.78 ± 6.23) ％) and 0.1 mg/kg group((22.42 ± 3.85) ％) were lower than that in control group((39.42 ±3.86)％,P＜0.05).Conclusion It is necessary for select right doses for model different endophenotypes of schizophrenia by MK-801.0.03 mg/kg of MK-801 is a relatively appropriate dosage to cause recognition memory damage.

Primary study of resting state functional magnetic resonance imaging in early onset schizophrenia using ReHo / 中南大学学报(医学版)

OBJECTIVE@#To explore the regional homogeneity of resting state brain activity in early onset schizophrenia using functional magnetic resonance imaging.@*METHODS@#Schizophrenia or schizophreniform disorder was diagnosed according to DSM-IV-TR (diagnostic and statistical manual of mental disorders, fourth edition, text revision). A total of 18 adolescents with early-onset schizophrenia (EOS; onset of psychotic symptoms by age 18) and 18 age- and gender-matched healthy volunteers were tested in a resting-state fMRI scan. Regional homogeneity approach was used to analyze the functional imaging data,and statistical parametric mapping 5 (SPM5)was used to perform t-test in ReHo maps between the patients and controls.@*RESULTS@#In comparison with the controls, the early-onset patients showed significantly decreased regional homogeneity in bilateral medial prefrontal cortex(P20), but no brain regions showed significantly increased regional homogeneity in the patients.@*CONCLUSION@#Regional homogeneity of resting state brain activities in EOS was decreased in bilateral medial prefrontal cortex. These abnormal changes may be involved in the psychopathology of schizophrenia.

The changement of serum CRP and the effect of fluvastatin on CRP in the patients with heart failure of CHD / 重庆医科大学学报

Objective; To observe the changement of serum c - reactive protein (CRP) and the effect of fluvastatin on CRP in the patients with heart failure of coronary heart diease (CHD). Methods ; 78 patients with CHFwere randomly divided into treated group and contol group , which were given usual treatment according to the guide of CHF treatment. Meanwhile, fluvastatin was added to the treated group . Two groups need to detected the TC , CRP and LEVF before and after treatment . Results : After 8 weeks , compared to the control group , the TC , CRP of the treated group decreased in varying degredd , but the LEVF increased obviously . Conclusion ; CRP can forecast dangerous of heart disease . It can be used as a index to prognose the patient with CHF . Fluvastatin can decrease the CRP and improve the prognosis for patient with CHF .