Effects of Estradiol Decreasing on Female Rat Salivary / 医学研究杂志

Objective In this research,the relationship between blood estrogen level and salivary glands of female rat was studied.Methods Thirty-two female Wister rats were randomly divided into four groups:control group,sham operation group,ovariectomized and injected estradiol benzoate group and ovariectomized group.Menopausal rat model was established by ovariectomy.By testing E2,histological examination and examing Cu,Zn-SOD expression through immunochemical staining,we studied the effects of estrogen decreasing on female rat salivary.Results Compared with control group,sham operation group,ovariectomized and injected estradiol benzoate group,a significant decrease in scrum estrogen level was observed in ovariectomized group(P