Analysis of allergens spectrum in children with allergic rhinitis in Zhengzhou district / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To analyze the main allergens in children with allergic rhinitis and provide scientific basis for prevention and treatment in Zhengzhou district.@*METHOD@#Twenty standardization allergens were used to perform skin prick test in 412 children with AR, and the results were statistically analyzed.@*RESULT@#Three hundred and twenty-nine of 412 cases (79.85%) showed positive reaction. The positive rate of dermatophagoides farina (87.54%) was the highest in inhaled allergens, followed by dermatophagoides pteronyssinus (86.32%), cat hair (62.31%), fungus I (47.72%) and dog hair (43.16%). The positive rate of shrimp (13.68%) was the highest in ingestive allergens, then egg (5.17%), carp (4.56%), meat I (3. 04%) and milk (3.04%).@*CONCLUSION@#Dust mites, cat hair, fungus,dog hair were the most common allergens in children in Zhengzhou district. Improving living environment of children with AR and avoiding contacting with allergens were pretty important.

Prevalence of sensitization to allergens in 1 139 patients with allergic rhinitis in Zhengzhou area / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To investigate the main allergens in patients with allergic rhinitis in Zhengzhou district.</p><p><b>METHODS</b>Twenty standardization allergens were used to perform skin prick test in 1 139 patients with allergic rhinitis. The samples were divided into four groups according to the age of the patients. The distributions of different allergens in the four groups were analyzed.</p><p><b>RESULTS</b>The top five inhaled allergens were dermatophagoides farina (920 cases, 80.8%), dermatophagoides pteronyssinus (870 cases, 76.4%), cat hair (517 cases, 45.4%), herbs (397 cases, 34.9%) and poaceae (353 cases, 31.0%); the top five ingestive ones were shrimp (143 cases, 12.6%), peanut (66 cases, 5.8%), egg (56 cases, 4.9%), carp (51 cases, 4.5%) and meat (48 cases, 4.2%). The distribution of allergens was different among the different age groups.</p><p><b>CONCLUSION</b>Dust mites, cat hair, herbs and poaceae were the most common allergens in Zhengzhou district.</p>

Development of the Chinese nasal obstruction symptom evaluation (NOSE) questionnaire / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To develop the Chinese version of the nasal obstruction symptom evaluation (NOSE) questionnaire.</p><p><b>METHODS</b>After introduction, forward and backward translation, synthesis, expert committee review, pretest, adaptation and validation followed the international guidelines, the Chinese version of NOSE scale was tested among 223 nasal septal deviation patients and 80 health volunteers to further assess its psychometric and clinical properties. SPSS 19.0 software was used to analyze the data.</p><p><b>RESULTS</b>The Chinese version demonstrated satisfactory evaluation results. The acceptance rate of the questionnaire was 97.6% and 94.1% in the patient group and control group respectively, and the completion time was (1.5 ± 0.5)min and (1.0 ± 0.5)min. Internal consistency reliability (Cronbach's α) was calculated to be 0.869. Test-retest reliability coefficient was adequate at rs = 0.996. Content validity was approved by our expert committee. Criteria validity (Spearman correlation coefficient) between NOSE Chinese version and SF-36, as well as VAS was -0.837 and 0.725 separately. Construct validity of Chinese version was similar to that of the original edition. The standardized response mean and the effect size at three months postoperatively was respectively 1.34 and 1.21, indicating high responsiveness. Calculated by Mann-Whitney U test, the instrument showed excellent sensitivity to discriminate the subjects with or without nasal obstruction (P < 0.01). The NOSE scores were also correlated with nasal resistance by rhinomanometry.</p><p><b>CONCLUSIONS</b>The NOSE Chinese version was successfully cross-cultural adapted and validated. It therefore can be recommended as a robust tool for future measuring subjective severity of nasal obstruction in China.</p>

The effect of two surgical method on treatment of allergic rhinitis complicated with nasal septum deviation / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To evaluate the effect of two surgical methods on treatment of allergic rhiniti complicated with nasal septum deviation.@*METHOD@#Eighty-seven cases of allergic rhiniti complicated with nasal septum deviation were divided into 2 groups according to the degree of mucosal hypertrophy and hyperplasia of bone in inferior turbinate. They were treated by resection of nasal septum deviation combined with temperature-controlled radio-frequency, or combined with partial submucoperiosteous resection of inferior turbinate bone. The Lanzhou standard (2004) and nasal airway resistance were used to evaluate the efficacy.@*RESULT@#After one year follow-up time, the nasal resistance was significantly decreased and the effective rates were greater than 88% in each group.@*CONCLUSION@#Both of the two surgical methods can significantly depress the nasal resistance and improve the allergic symptoms, which shows good effect.

Transplantation of bone-marrow derived mesenchymal stem cells to treat rat retinal degeneration / 中华眼底病杂志

Objective To observe the effects of subretinal transplantation of rat mesenchymal stem cells (rMSCs) on Sodium Iodate (SI)-induced retinal degeneration.Methods One hundred and twenty Brown-Norway (BN) rats were divided into three groups including SI injection group,rMSCs transplantation group and normal control group,each with 40 rats.The retinal degeneration was induced by caudal vein injection of SI.The retinal pigment epithelium(RPE)and neural retinal were evaluated by ocular fundus photograph,fluorescein fundus angiography (FFA),electroretinogram (ERG) and histological approach,and TUNEL(terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling).CM-Dilprelabeled primary rMSCs were transplanted into the subretinal space of Sl-induced rats.The survival,integration,and differentiation of rMSCs were observed between 14 day to 60 day after the transplantation.Results The rat retinal function was gradually reduced afterl4 days of SI injection,with a time-dependent manner.After the RPE cells were damaged,the outer segments of photoreceptors became disrupted and shortened until karyopyknosis.The nuclear morphology and positive TUNEL labeling indicated that the death of photoreceptor cells was apoptosis.After rMSCs transplantation,CM-DiI labeled donor cells were observed to be scattered in the subretinal space and expressed RPE cell markers.Average amplitude of bwave and Ops (oscillation potential) in ERG improved 27.80%,59.38% respectively after rMSCs transplantation.Conclusions Transplanted rMSCs can survive in subretinal space and differentiate into RPE cells,thus cure SI- induced retinal degeneration.