ABSTRACT
<p><b>OBJECTIVE</b>To prepare flexible proanthocyanidins nanoliposomes, and explore the in vitro release behavior of proanthocyanidins flexible nanoliposomes and general nanoliposomes.</p><p><b>METHOD</b>Flexible proanthoeyanidins nanoliposomes were prepared proanthocyanidins using a film dispersion method, characterized by transmission electron microscope, and the in vitro release action was studied in different dissolution mediums using dynamic dialyse method with the content of total phenol as index.</p><p><b>RESULT</b>The in vitro release of both proanthocyanidins flexible nanoliposomes and general nanoliposomes were in accordance with Weibull distribution.</p><p><b>CONCLUSION</b>Proanthocyanidins flexible nanoliposomes without pressure had similar in vitro release behavior with general nanoliposomes.</p>