ABSTRACT
OBJECTIVE@#To explore clinical effect of arthroscopic debridement combined with platelet-rich plasma (PRP) injection for Kellgren-Lawrence(K-L) gradeⅠ-Ⅲ knee osteoarthritis (KOA) .@*METHODS@#Totally 117 patients with KOA who underwent arthroscopic debridement combined with injection from November 2015 to January 2019 were retrospectively analyzed. According to different injection drugs, the patients were divided into sodium hyaluronate group(group A) and PRP group(group B). In group A, there were 60 patients, including 27 males and 33 females, aged from 49 to 67 years old with an average age of (54.1±4.8) years old;12 patients with gradeⅠ, 23 patients with gradeⅡand 25 patients with grade Ⅲ according to K-L clssification, 2 ml(20 g) sodium hyaluronate was injected into knee joint after intraoperative, 1, 2, 3 weeks after operation for 4 times. In group B, there were 57 patients, including 25 males and 32 females, aged from 47 to 70 years old with an average of (55.8±5.0) years old, 10 patients with gradeⅠ, 20 patients with gradeⅡand 27 patients with grade Ⅲ according to K-L classification, injected 5 ml PRP at the same time. Postoperative complications was recorded between two groups. Postoperative visual analogue scale(VAS) and Lysholm score at 3, 6, 12 months were used to evaluate improvement of knee pain and joint function.@*RESULTS@#All patients were followed up for 12 to 19 months with an average of (14.1±1.6) months. There was no significant difference in postopertaive complications between group A and group B (P>0.05). Postoperative VAS score in group A at 3, 6, 12 months were 3.0±0.8, 2.0±0.8, 2.6±0.9 respectively, and 2.9±0.8, 1.9±0.7, 2.2±0.8 in group B respectively; and no differnece at 3 and 6 months after operation between two groups (P<0.05), while VAS score in group B was higher than group A at 12 months after operation(P<0.05). Postoperative Lysholm score in group A at 1, 6, 12 months (86.6±1.8, 93.1±2.0, 86.7±1.7) were lower than group B(88.9±1.9, 95.0±2.0, 89.0±1.9)(P<0.05).@*CONCLUSION@#Arthroscopic debridement combined with sodium hyaluronate or PRP injection for K-L gradeⅠ-Ⅲ KOA could effectively relieve pain and improve joint function with higher safety in short term, but the medium-long-term effect of PRP injection is stable.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Debridement , Injections, Intra-Articular , Osteoarthritis, Knee/surgery , Platelet-Rich Plasma , Retrospective Studies , Treatment OutcomeABSTRACT
Objective:To find the better imaging method for the diagnosis of sialolithiasis by comparing the 3 different imaging methods.Methods:32 cases of salivary calculus were examined by sonography,X-ray and cone beam computed tomography(CBCT),the sensitivity,specificity,positive predictive value,negative predictive value were compared among the 3 methods.Results:The sensitivity and negative predictive value of cone beam computed tomography(95.8％ and 80％) was significantly higher than those of sonography(83.3％,50.0％) and X-ray(58.3％,20％)(P ＜ 0.05).Of three imaging methods there was no statistical difference in specificity and positive predictive value.Conclusion:CBCT is more sensitive than sonography or X-ray in the diagnosis of sialolithiasis.
ABSTRACT
Objective To explore the correlation between the severity of osteoarthritis and the serum levels of interleukin-4 (IL-4) and soluble IL-4 receptor (sIL-4R). Methods Fifty patients with osteoarthritis hospitalized from May 2011 to May 2013 were selected as study group, and 50 healthy individuals during the corresponding period were selected as control group. The serum levels of IL-4 and sIL-4R were determined by EILISA and compared between the two groups. The severity of osteoarthritis of patients in the study group was assessed by Kellgren and Lawrence (K&L) grading system and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The relationship between both K&L grade and WOMAC scores and the serum levels of IL-4 and sIL-4R was analyzed. Results The serum level of sIL-4R in the study group (82.12±11.24ng/ml) was significantly higher than that in control group (30.67±5.23ng/ml, P0.05). The serum level of sIL-4R in the study group was positively correlated with the WOMAC scores (r=0.313, P<0.05). The sIL-4R levels were increased gradually along with the increase in K&L grade, and the difference between different grades was significant (P<0.05). Conclusion The serum level of sIL-4R is correlated with the severity of osteoarthritis, and may be used as an evaluation indicator of severity of osteoarthritis.