ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the antioxidant activity of astragalus and its therapeutic effect on gestational diabetes.</p><p><b>METHODS</b>Eighty-four pregnant women with gestational diabetes were divided into insulin and insulin plus astragalus groups after regular dietary control and insulin treatment to maintain stable blood glucose level. The 43 patients in insulin group received insulin injection, whereas the 41 patients in the other group received treatment with both insulin and astragalus. The SOD activity, MDA level, blood lipids and renal function were determined in both groups after the treatments.</p><p><b>RESULTS</b>The patients with both insulin and astragalus treatments showed significantly increased serum SOD activity and decreased MDA level, renal function and blood lipids in comparison with those with exclusive insulin treatment.</p><p><b>CONCLUSION</b>Astragalus can effectively control blood glucose, reduce the free radicals, and promote the antioxidative activity, and may play a role in the prevention and treatment of gestational diabetes.</p>
Subject(s)
Female , Humans , Pregnancy , Antioxidants , Metabolism , Astragalus Plant , Diabetes, Gestational , Drug Therapy , Metabolism , Drugs, Chinese Herbal , Therapeutic Uses , Malondialdehyde , Metabolism , Oxidation-Reduction , Phytotherapy , Superoxide Dismutase , Metabolism , Treatment OutcomeABSTRACT
Objective To analyse the causes of perinatal death and explore the preventive measures to reduce the perinatal mortality.Methods The cases with perinatal death in this hospital from January 2005 to December 2006 were reviewed to analyse the causes of death by categorization and sum-up.Results There were 166 cases with perinatal death and the mortality rate was 27.08‰,including 126 cases with fatal death,which accounted for 75.90%.In the analysis of dead causes,the first one was birth defects,which suffered 69 cases,41.57% of all,and mostly were with fetus edema syndrome.The cord factors had been elevated to the second cause,which suffered 51 cases,30.72% of all.Conclusion Improving the consciousness of gestational monitoring and self-care,strengthening the prenatal diagnosis and genetic counseling,controlling the perinatal birth defects,monitoring mother and fetus by poly-parameter and stopping the pregnancy in time can reduce perinatal death effectively.