ABSTRACT
Objective: To explore the correlation among serum levels of carbohydrate antigen 125 (CA125), uric acid (UA) and cardiac function in advanced aged patients with chronic heart failure (CHF). Methods: A total of 110 advanced aged inpatients were enrolled. According to NYHA cardiac function classification, they were divided into heart failure (HF) group (n=65, including 30 cases of class II and 35 cases of class III～IV) and normal cardiac function group (n=45). Levels of CA125, CA199, carcino-embryonic antigen (CEA), UA and N terminal pro brain natriuretic peptide (NT-proBNP), mitral early diastolic peak flow velocity/mitral late diastolic peak flow velocity (E/A) and left ventricular ejection fraction (LVEF) were measured and compared between two groups and between patients with difference NYHA class. Results: Compared with normal cardiac function group, there were significant rise in levels of CA125 [(15. 9±6. 3) U/ml vs. (40. 1±12. 2) U/ml], UA [(319. 2±61. 3) μmol/L vs. (435. 7±72. 9) μmol/L]and NT-proBNP [(298. 5±132. 4) pg/ml vs. (1923. 7±868. 6) pg/ml], and significant reductions in E/A [(1. 02±0. 46) vs. (0. 71±0. 25)] and LVEF [(62. 1±11. 9) ％ vs. (48. 7±14. 7) ％]in HF group, P=0. 001 all. Compared with class II group, there were significant rise in levels of CA125 [(28. 4±9. 3) U/ml vs. (50. 1±13. 9) U/ml], UA [(383. 4±71. 8) μmol/L vs. (478. 4±73. 9) μmol/L]and NT-proBNP [(853. 2±361. 5) pg/ ml vs. (2841. 3±1303. 3) pg/ml], and significant reductions in E/A [(0. 78±0. 23) vs. (0. 65±0. 19)] and LVEF [(52. 6±10. 1) ％ vs. (45. 3±13. 1) ％]in class III～IV group, P＜0. 05 or＜0. 01. Pearson linear correlation regression analysis indicated that levels of CA125, UA and NT-proBNP were significant inversely correlated with E/A and LVEF in HF group (r=-0. 679～-0. 457, P＜0. 05 or＜0. 01). Conclusion: Levels of CA125, UA and NT-proBNP are significant inversely correlated with LVEF in advanced aged CHF patients, which help to determine HF severity.