ABSTRACT
In order to get to know the imitation of wild Gastrodia elata in life history and phenology period, by G. elata f. elata forest wild simulated cultivation in Dafang county, Guizhou province, observing and recording its morphological characteristics of each growth and development stage. This experiment summarized the law of its life history over 24 months, amplified the characteristics of each 5 phenology periods over the sexual and asexual reproduction of wild simulated cultivated G. elata f. elata in Guizhou. Which the results could clear the process of wild simulated cultivated G. elata f. elata in Guizhou, and provide a theoretical support for the standard technical of the simulated wild G. elata.
Subject(s)
Gastrodia , Physiology , Life Cycle Stages , Physiology , ReproductionABSTRACT
In order to explore the rules of combined Chinese and Western medical treatment on immune infertility, the study was carried out by searching relative primary documents from databases and 26 articles (dealing with 5865 cases) were screened out. Excel was used to perform the frequency analysis on the Western drugs and 27 Chinese recipes emerging in the documents separately. It was discovered that the combined use of Chinese and Western medicines has its superiority. Low dose glucocorticoids together with vitamine is the main Western treatment used, and dexamethasone is the most frequently used preparation of glucocorticoids. Among the 72 Chinese drugs presented in the 27 Chinese recipes, 13 appeared for more than 1800 times, they were Angelica sinensis, Salvia miltiorrhiza, Radix Paeoniae Rubra, Radix Astragali, Poria, Carthamus tinctorius, Phellodendron amurense, Scutellaria baicalensis, Anemarrhena asphodeloides, Rehmannia glutinosa, Cuscuta chinensis, Radix Paeoniae Alba and Radix Glycyrrhiza.
Subject(s)
Female , Humans , Angelica sinensis , Astragalus Plant , Bibliometrics , Carthamus tinctorius , Drugs, Chinese Herbal , Therapeutic Uses , Glucocorticoids , Therapeutic Uses , Infertility, Female , Drug Therapy , Allergy and Immunology , Integrative Medicine , Methods , Phytotherapy , Plant Extracts , Rehmannia , Salvia miltiorrhiza , Scutellaria baicalensisABSTRACT
<p><b>OBJECTIVE</b>To evaluate the safety and immunogenicity of the Bilive(TM) combined hepatitis A and hepatitis B vaccine in healthy children.</p><p><b>METHODS</b>A total of 116 healthy children aged 1 - 10 years, who, without history of hepatitis A vaccine vaccination and anti-HAV negative, had completed the full immunization of hepatitis B vaccine were recruited in city of Changzhou in Jiangsu province. The Bilive(TM) combined hepatitis A and hepatitis B vaccine was administered according to a two-dose schedule (0, 6 months). The dosage was 250 U for hepatitis A antigen and 5 microg for hepatitis B surface antigen. The potential adverse effects were observed within 72 hours after vaccination. The serum samples were collected for the testing of anti-HAV and anti-HBs at month 1, 6 and 7 after initial dose.</p><p><b>RESULTS</b>The local and systemic adverse reactions after immunization were slight and temporary. The rates of local and systemic adverse reactions were 12.1% (14/116) and 6.0% (7/116). The sero-conversion rates of HAV were from 92.9% (92/99) to 100.0% (101/101) and the geometric mean titers (GMT) ranged from 47.0 mIU/ml to 2762.3 mIU/ml 1, 6, 7 months after initial dose. The sero-protection rate of HBV was 86.1% (87/101) before vaccination and came up to 100.0% (101/101) one month after initial dose, and the GMTs of HBV were from 894.3 mIU/ml to 3314.3 mIU/ml 1, 6, 7 months after initial dose.</p><p><b>CONCLUSION</b>The Bilive(TM) combined hepatitis A and hepatitis B vaccine has good safety and immunogenicity in healthy children who had preexisting immunity to hepatitis B virus.</p>
Subject(s)
Child , Child, Preschool , Female , Humans , Infant , Male , Dose-Response Relationship, Immunologic , Hepatitis A Vaccines , Allergy and Immunology , Hepatitis B Vaccines , Allergy and Immunology , Immunization Schedule , Vaccines, Combined , Allergy and ImmunologyABSTRACT
Objective To evaluate the immunogenicity, safety, stability and consistency of three consecutive lots of a inactivated hepatitis A vaccine (Healive(R)). Methods A double-blind, randomized and controlled clinical trial was conducted in healthy volunteers aged from 1 to 8 years. Totally, 400 subjects were enrolled and assigned into four groups, each receiving one of the three lots of Healive(R) or an licensed control vaccine in 0 and 6th month. Safety was assessed through a 30 minutes and three days observation,thereafter. Anti-HAV titers were determined on the 1st, 6th and 7th month after the vaccination.Results Seroconversion rate of four groups were all 100% by the end of the schedule while GMTs of Healive(R) were 3237.06-3814.14 mIU/ml but were not significantly different. GMT of control vaccine was 1467.49 mIU/ml. Healive(R) and control vaccine were well tolerated with 1%-5% incidence of overall adverse reactions in which most of them were mild and moderate. No severe adverse reaction was reported.Conclusion The three consecutive lots of Healive(R) were well consistent as indicated by immunogenicity and safety while immunogenicity was better than the vaccine used as control.