ABSTRACT
Objective:To evaluate the effect of special teaching on anti-bacterial drugs that applied the problem-based learning combined with case-based learning.Method:s A total of 100 pharmaceutical students who participated in internships in Qujing First People's Hospital of Yunnan Province from 2018 to 2019 were included. According to the career plan after graduation, the students were divided into experimental group (to be engaged in clinical pharmacy) and control group (to be engaged in drug dispensing). There were 50 people in the experimental group, who received the problem-based learning combined with case-based learning teaching mode on the basis of traditional theoretical teaching (basic theoretical knowledge teaching). There were 50 people in the control group, who received only the traditional teaching mode. After the internship, the quality of teaching was assessed through examinations and questionnaires.Result:s There were no significant differences in the overall scores and individual scores of the objective questions ( P>0.05). The overall scores and individual scores of the case analysis of the experimental group were significantly higher than those of the control group ( P<0.05). The enthusiasm and initiative, and ability of clinical thinking, innovative practice, communication, team work of the experimental group were significantly better than those of the control group ( P<0.01). Conclusion:The problem-based learning combined with case-based learning teaching method is superior to the traditional theoretical teaching mode, which can significantly improve the teaching quality of antimicrobials for pharmacy interns. It is worth being promoted in teaching.
ABSTRACT
OBJECTIVE: To probe the role of clinical pharmacists in drug use of patients with severe pneumonia. METHODS: Clinical pharmacists participated in the treatment for a patient with ESBLs producing Klebsiella pneumoniae severe pneumonia. The patient was given cefoperazone tazobactam combined with moxifloxacin and ganciclovir initially. Clinical pharmacists suggested stopping cefoperazone tazobactam and moxifloxacin and additionally using meropenem according to the elevation of hemogram infection indexes; suggested stopping ganciclovir and continuously using meropenem according to the results of sputum culture; suggested providing cefoperazone sulbactam de-escalation sequential therapy for ESBLs producing Klebsiella pneumoniae and stopping cefoperazone sulbactam and azithromycin according to clinical symptoms of the patient. RESULTS: The physicians adopted the suggestions of clinical pharmacists. After treatment, body temperature and lab indexes of the patient recovered to normal; the result of sputum culture turned to negative. Chest CT showed that the infection focus was obviously absorbed compared to before. After discharged from hospital and followed up, the patient was found to have a good prognosis. CONCLUSIONS: Through actively participating in drug therapy, based on lab indexes and results of sputum culture, clinical pharmacists provide pharmaceutical care and adjust medication plan to improve treatment rate of patients with severe pneumonia and the safety and effectiveness of drug treatment, be of great significance to promote the rational use of antibiotics.