ABSTRACT
Infantile spasms(IS)is an age-dependent severe epilepsy syndrome, mainly treated with hormones and anti-seizure medications.However, due to poor efficacy and even serious side effects among some pediatric patients, searching for better alternative treatment options has become a research hotspot.In recent years, as a special diet treatment, ketogenic diet(KD)has been widely studied and gradually applied to the clinical treatment of IS, which has achieved satisfactory results.This article briefly reviews the KD regimen and mechanism of action, and focuses on the research progress in efficacy, safety and short-term prognosis of KD in the treatment of IS, whose purpose is to provide effective reference for clinical application.
ABSTRACT
Febrile infection-related epilepsy syndrome is a rare and one of the most serious epileptic encepha-lopathy.It commonly affects school-aged children who are healthy previously and have a normal developmental history.The patients suffer from a progressively worse seizure after several days of a nonspecific prior febrile and abruptly develop status epilepticus.It remains unclear about its etiology and pathogenesis.Although there is a lack of specific biological markers, poor treatment outcomes would usually be achieved, early identification and reasonable treatment may improve the prognosis.
ABSTRACT
Myelin oligodendrocyte glycoprotein(MOG)is expressed in oligodendrocytes of the mammalian central nervous system, which is located on the surface and an important component of the myelin sheath.MOG antibody related inflammatory demyelinating disease is a hot topic in the field of neurology in recent years, and its clinical phenotype spectrum varies.Currently, cell-based assay(CBA)is recommended to detect MOG antibodies in peripheral blood.Due to the complexity and diversity of the clinical manifestations, and different manifestations in different age groups, it is difficult to make the clinical diagnosis.The exact pathogenesis is still unclear, and the therapeutic options and long-term prognosis remain controversial.In this article, the pathogenesis, clinical manifestations, treatment options and clinical prognosis of MOG antibody related inflammatory demyelinating diseases will be reviewed.
ABSTRACT
In the past 20 years, new anti-epileptic drugs have been constantly developed, but the percentages of patients who suffer from refractory epilepsy have not been significantly decreased.Therefore, to find out a drug that can effectively reduce seizures with relatively fewer side effects has become an urgent issue.In recent years, the treatment of epilepsy based on Cannabis has drawn great public attention.Cannabidiol, which is purified from Cannabis, can relieve refractory epilepsy in children.The present findings of research are summarized in this paper.
ABSTRACT
To explain how to ensure and improve the quality of the clinical practice teaching for the clinical institutes,we expatiate on the practical experience in the hospital from enhancing the practice teaching management,improving the teaching consciousness,meliorating the teaching environment and reforming the method.