ABSTRACT
The loss of dopaminergic neurons and the decreased release of dopamine neurotransmitters in the substantia nigra pars compacta are the main pathological mechanisms leading to Parkinson 's disease (PD) in clinical research. Under the combined influence of genes and environment, there are many death mechanisms of dopaminergic neurons. Current research suggests that apoptosis, necrosis and autophagic death all participate in the death of dopaminergic neurons, but these deaths are not sufficient to explain their pathological processes and mechanisms. Ferroptosis is a newly discovered iron-dependent cell death pathway characterized by increased iron load and accumulation of large amounts of lipid peroxides. These characteristics are highly consistent with the clinical molecular characteristics of the brain in PD patients. In addition, there is evidence that ferroptosis and oxytosis (observed in nerve cells 30 years ago) have a high degree of similarity in signal regulation, and they may represent the same form of programmed cell death. This review discusses the current advances of ferroptosis death pathway in PD, and briefly discusses the possibilities for ferroptosis and oxytosis as the same type of cell death. The elucidation of the death pathway and mechanism of dopaminergic neurons can provide a fundamental theoretical basis for the development of anti-PD drugs.
ABSTRACT
OBJECTIVE:To study the chemical constituents in the chloroform extract of Fructus Canarii. METHODS:The chloroform extract of Fructus Canarii was isolated and purified by MCI,Toyopearl HW-40F,reverse-phase C18,Sephadex LH-20 column. The structure of compounds was analyzed and identified by physicochemical properties and spectral data(mass spectrum, hydrogen spectrum and carbon spectrum). RESULTS:Eight compounds were isolated from chloroform extract of Fructus Canarii, namely Dihydrophaseicacid-3′-O-β-D-glucopyranoside(1),3,4-Dihydroxybenzoic acid(2),3-O-galloylquinic acid(3),Gallic acid (4), Ethyl gallate(5), Scopoletin(6), Dllagic acid-4-O-α-L-rhamnopyranoside(7) and Isocorilagin(8). CONCLUSIONS:Compounds 1,2 and 7 were firstly obtained from Fructus Canarii. The study lays foundation for quality evaluation of Fructus Canarii.
ABSTRACT
According to the specialty characteristics of medical college and university and the reality of teaching on the analytic chemistry experiment,this article explored a new thought on teaching of analytic chemistry experiment for majors of medicine and pharmaceutics.By optimizing the course teaching system,enhancing the requirement of experience teaching,renewing the teaching contents and integrating basal experiment with integrated and designed experiment,we obtained good teaching effect.