ABSTRACT
Objective@#To investigate the correlations of indexes of isokinetic muscle testing with grip, the circumference of muscle, the time up and go test(TUGT), and the distance of 6-minutes walk test(6MWT). And to identify the availability of isokinetic muscle testing in diagnosing sarcopenia in the elderly.@*Methods@#A total of 27 elderly patients with sarcopenia admitted in rehabilitation department of our hospital from Jan.2017 to Dec.2017 were enrolled in this cross-sectional study.Patients were evaluated in many aspects, including comprehensive evaluation by the comprehensive assessment, the skeletal muscle mass detection by dual energy X-Ray absorptiometry, the power of gripping by dynamometer, the circumference of muscle of upper and lower extremities, the muscle strength by isokinetic muscle testing, the sports ability by TUGT and 6MWT.@*Results@#Isokinetic muscle testing including the knee flexion, knee extension, elbow extension, wrist extension, TUGT, 6MWT, the power of left gripping, the circumference of left forearm muscle showed a negative correlations to the age(r=-0.54, -0.44, -0.52, -0.61, -0.53, -0.41 and-0.39, P<0.05). A positive correlation were observed between TUGT and the age(r=0.44, P<0.05). The positive correlations between every index in isokinetic muscles testing and the power of both left and right gripping were observed(r=0.66, 0.67, 0.67, 0.67, 0.56, 0.62, 0.54, 0.54, 0.64, 0.59, 0.59 and 0.56, P<0.05). The knee flexion, knee extension, elbow flexion, elbow extension and wrist extension of Isokinetic muscle testing showed a positive correlations to 6MWT(r=0.71, 0.65, 0.62, 0.60 and 0.59, P<0.05). The knee flexion, knee extension, elbow extension and wrist extension of isokinetic muscle testing showed a negative correlations to TUGT(r=-0.57, -0.52, -0.42 and-0.48, P<0.05). Every index of isokinetic muscle testing showed a positive correlations to the circumference of both forearms(r=0.45, 0.47, 0.52, 0.42, 0.41, 0.44, 0.49, 0.52、0.60, 0.54, 0.44 and 049, P<0.05).@*Conclusions@#Isokinetic muscle testing can accurately evaluate the changes of muscle strength in the elderly with sarcopenia.It can be considered as the reference index of motor function in diagnosing sarcopenia in the elderly.
ABSTRACT
Objective To investigate the correlations of indexes of isokinetic muscle testing with grip,the circumference of muscle,the time up and go test(TUGT),and the distance of 6-minutes walk test(6MWT).And to identify the availability of isokinetic muscle testing in diagnosing sarcopenia in the elderly.Methods A total of 27 elderly patients with sarcopenia admitted in rehabilitation department of our hospital from Jan.2017 to Dec.2017 were enrolled in this cross-sectional study.Patients were evaluated in many aspects,including comprehensive evaluation by the comprehensive assessment,the skeletal muscle mass detection by dual energy X-Ray absorptiometry,the power of gripping by dynamometer,the circumference of muscle of upper and lower extremities,the muscle strength by isokinetic muscle testing,the sports ability by TUGT and 6MWT.Results Isokinetic muscle testing including the knee flexion,knee extension,elbow extension,wrist extension,TUGT,6MWT,the power of left gripping,the circumference of left forearm muscle showed a negative correlations to the age(r=-0.54,-0.44,-0.52,-0.61,-0.53,-0.41 and-0.39,P ＜0.05).A positive correlation were observed between TUGT and the age (r =0.44,P ＜ 0.05).The positive correlations between every index in isokinetic muscles testing and the power of both left and right gripping were observed(r =0.66,0.67,0.67,0.67,0.56,0.62,0.54,0.54,0.64,0.59,0.59 and 0.56,P＜0.05).The knee flexion,knee extension,elbow flexion,elbow extension and wrist extension of Isokinetic muscle testing showed a positive correlations to 6MWT(r =0.71,0.65,0.62,0.60 and 0.59,P＜0.05).The knee flexion,knee extension,elbow extension and wrist extension of isokinetic muscle testing showed a negative correlations to TUGT (r =-0.57,-0.52,-0.42 and-0.48,P＜0.05).Every index of isokinetic muscle testing showed a positive correlations to the circumference of both forearms(r =0.45,0.47,0.52,0.42,0.41,0.44,0.49,0.52、0.60,0.54,0.44 and 049,P＜0.05).Conclusions Isokinetic muscle testing can accurately evaluate the changes of muscle strength in the elderly with sarcopenia.It can be considered as the reference index of motor function in diagnosing sarcopenia in the elderly.
ABSTRACT
Objective To observe the effects of low intensity electromagnetic fields (LIEMFs) in promoting the reconstruction of full skin loss wounds grafted with human epidermal stem cells (ESCs). Methods Fifty nude mice aged 7 to 8 weeks with full skin loss wounds were equally divided into 3 experimental subgroups ( 1 Hz, 10Hz and 50Hz) and two control groups (a cell suspension control group and a blank control group) , with ten mice each. In the 3 experimental subgroups and the cell suspension control group, ESCs separated from human foreskin and cultured in vitro were grafted to the wounds using collagen sponge scaffolds. The experimental subgroups were then stimulated with an LIEMF (magnetic field intensity 5mT) at the appropriate frequency for 30min/day for 15 days. The blank control group was put under the same conditions without the cell suspension and LIEMF. The healing rates of the wounds were observed, and tissue slices were stained and observed under a light microscope. The inner structure of the regenerating skin was observed using transmission electron microscopy. Results The ESCs were successfully grafted. A few human integrin β1 positive stained cells appeared in the regenerating skin. The average healing rates in the experimental subgroups were significantly superior to those of the control groups. Well differentiated epidermis and dermis could be seen in the regenerating skin in all of the experimental groups. The epidermis had more cell layers and was thicker than in the control groups. More desmosome, hemidesmosome and keratin filaments were seen among the epidemic cells of the experimental groups. Conclusions LIEMF promotes the healing of full skin loss wounds grafted with ESCs in nude mice, and can promote complete repair of skin defects and the regeneration of skin function.