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1.
Article in Chinese | WPRIM | ID: wpr-477043

ABSTRACT

OB J ECT I V E To explore the adjacentpatterns between adenoid and Eustachian cushion in hypertrophic adenoid children and to study its relationship with otitis media with effusion(OME). METHODS A retrospective analysis was conducted in 144 cases of pediatric adenoidal hypertrophy(or concurrenttonsil hypertrophy) admitted for adenoid ablation under the 700 nasal endoscope. Children were divided into 3 groups(TypeⅠ, Ⅱ and Ⅲ) according to adjacentpatterns between adenoid and Eustachian cushion.The incidence of OME, severe hypertrophy of adenoid(A/N>0.7) in differentgroup were analyzed. RESULTS There were 34 children (23.6%) with OME, 3 (9.1%) in type Ⅰ, 10(16.9%) in type Ⅱ and 21(40.4%) in type Ⅲ. No significantdifference was existed between the incidence of OME in type Ⅰ and Ⅱ. In contrast, significantdifference were found in the incidence of OME between the type Ⅲ and type Ⅰ, Ⅱ. The incidence of severe adenoid hypertrophy was 34.9% in typeⅠandⅡ children and 82.2% in type Ⅲ children(P<0.05). CONCLUSION Adjacentpatterns between adenoid and Eustachian cushion, the degree of adenoid hypertrophy play an importantrole in the incidence of OME.

2.
Pakistan Journal of Pharmaceutical Sciences. 2014; 27 (4): 859-864
in English | IMEMR | ID: emr-152594

ABSTRACT

The antioxidant effects of the triterpenoid-rich extracts from Euryale ferox shell [ES] have been confirmed in vitro. This study examined whether the triterpenoid-rich extract from ES eases human hyperglycemia and diabetes caused by metabolic disorders. Normal and streptozocin [STZ]-induced diabetic mice were used as controls for the four groups that received the triterpenoid-rich extracts of ES suspended in distilled water orally at doses of 200, 300, 400, 500 +/- 2 mg/L. Body weight, blood glucose and pancreatic tissue morphology were observed after 4 weeks. The expression of protein tyrosine phosphatase-1B [PTP1B] and insulin receptor substrate [IRS-1] proteins, which are related to the regulation of glucose metabolism in vivo, were also investigated. Compared with the model group [LD[50] 900 +/- 2 mg/L], it was found that the triterpenoid-rich extracts of ES could regulate glucose metabolism [P<0.01] and cause body weight to return to normal levels [P<0.05]. Islet morphology recovered well, the expression of the negative regulation protein PTP1B gene was reduced and insulin receptor IRS-1 protein expression was increased. These data prove that the triterpenoid-rich extracts from ES have a therapeutic effect on diabetes by insulin resistance

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