Network pharmacological studies of Guanxin Qiwei tablet in treating coronary heart disease / 第二军医大学学报

Objective To clarify the active ingredients of Guanxin Qiwei tablet,and to explore the potential target for its efficacy.Methods We studied the interaction between Chinese medicine ingredients in the Guanxin Qiwei tablet and the therapy targets using a network pharmacology model,which was developed by integrating oral bioavailability prediction,druggability analysis,principal component analysis,molecular docking simulation and network of pharmacophore-target-disease analysis.Results Eighteen principal compounds had high-degree network with 41 therapy targets for coronary heart disease (CHD),and had higher affinity with 18 potential targets via the calculation of molecular docking.Further analysis showed that 7 key targets were closely related to the treatment of CHD.Conclusion We have screened 18 possible active molecules in Guanxin Qiwei tablet and 7 key therapy targets,and preliminarily elucidate the molecular mechanism based on the multi-ingredient,multi-target,and synergistic effect.

Imaging Diagnosis of Congenital Cholangiectasis:A Report of 6 Cases and Review of Literature / 实用放射学杂志

Objective To study the imaging value in diagnosis of congenital cholangiectasis.Methods The clinical and imaging (CT and ultrasonics) data of 6 patients with congenital cholangiectasis were restrospectively analyzed with literature review.Results According to Todani's classifications of cholangiectasis,there were type I in one case,CT showed cystic hypodense shadow with thin and smooth wall;type IV in 4 cases,CT showed cystic or fusiform extension of intra-and extra-hepatic bile ducts;type V in one case,CT showed cystic extension of intra-hepatic bile ducts,and the central spot enhancement could be seen on contrast-enhanced CT scan.6 cases underwent ultrasonic examinations,ultrasound showed extension of intra-and extra-hepatic bile ducts in 6 cases,choledochal cyst in one.4 cases suspected with congenital cholangiectasis,and misdiagnosed in one.In company with cholecystitis and cholelithiasis in one,biliary carcinoma in one and cirrhosis in one.Conclusion CT and US are of important value in diagnosis of congenital cholangiectasis.