ABSTRACT
Objective@#To understand the fruit consumption of adults of Qingdao and examine the association between fruit consumption and stroke.@*Methods@#We analyzed baseline data and stroke incidence of the participants who were aged 30-79 years and had been enrolled into the China Kadoorie Biobank (CKB) study from Qingdao city. Cox proportional hazards regression model was conducted to estimate the association of fruit consumption with risk of stroke.@*Results@#A total of 35 509 participants were investgated in the baseline survey. Ratio of male to female was 1∶1.27, and the average age was (50.3±10.2) years. Respondents with higher frequency of fruit consumption were younger, more women, with higher education level and higher income (P<0.05). A total of 1 011 new cases of stroke were observed, with a stroke incidence of 387.63/100 000 person-years. Multivariate Cox regression analysis showed that fruit consumption had a protective effect on stroke incidence. Compared to the respondents who never consumed fruit, respondents who consumed fruit more than 4 days per week had a 44% lower risk of stroke incidence (HR=0.56, 95%CI: 0.50-0.62, P<0.05), and the risk reduced by 46% (HR=0.54, 95%CI: 0.46-0.64, P<0.05) and 42% (HR=0.58, 95%CI: 0.52-0.69, P<0.05) in male and female, respectively. Further adjustment for WC, BMI, SBP and random blood glucose did not change the association.@*Conclusion@#Increasing fruit consumption can effectively decrease the risk of stroke. People should increase fruit consumption advisably to set up reasonable and healthy dietary habits.
ABSTRACT
Objective To investigate the relationship between matrix metalloproteinase-9 (MMP-9) gene polymorphism and delayed cerebral edema in patients with hypertensive intracerebral hemorrhage (HICH).Methods 137 HICH patients were recruited to participate in the study.According to whether combined with delayed cerebral edema,they were divided into the case group (42 cases) and the control group (95 cases).Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-FLP) for MMP-9 gene-1562C/T polymorphism.Clinical data was collected for statistical analysis.Results There was significant difference in age,diabetes,persistent fever,baseline hematoma volume and National Institute of Health Stroke Scale (NIHSS) between the case group and the control group (all P ＜ 0.05).Meanwhile,serum MMP-9 level of the case group was significantly higher than that of the control group [(176.7 ± 50.3) mg/L vs (145.8 ± 41.3) mg/L,P =0.000].There were significant difference in serum MMP-9 level between genotype CC and genotype (CT + TT) [(147.3 ± 45.0) mg/L vs (189.2 ± 59.4)mg/L,P =0.000].Compared with the control group,the distribution frequencies of allele T in the case group was significantly increased (P =0.019).Multivariatc Logistic regression analysis showed that Allele T was a risk factor of delayed cerebral edema for HICH patients (OR =2.612,95％ CI:1.187-6.670,P =0.005).Conclusions For spontaneous HICH patients,MMP-9 gene-1562C/T polymorphism may closely related to delayed cerebral edema.
ABSTRACT
The determinations of total extracting flavone content and total extracting solid yield of roots or stems of Radix Ilieis Pubescentis and their contrast studies in pharmacodynamics and toxicology have been carried out.As a result,no significant difference between roots and stems,which provide the basis for mixed use of roots and stems of Radix Ilicis Pubescentis.