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Objective To explore the effect of jejunum tube implantation on the reduction of adverse reactions,outcomes improvement and cost reduction in esophageal cancer patients with radiotherapy. Methods Eighty-two esophageal cancer patients with nutritional risk in Beijing Chaoyang District Huanxing Cancer Hospital from August 2014 to December 2016 were analyzed. Forty-one cases received jejunum tube implantation (implantation group) and 41 cases received non-nutrient tube implantation (control group), and data on their nutritional status,clinical efficacy,adverse reactions,and hospitalization costs were collected and compared. Results Compared with the control group, the implantation group has higher body mass index [(21.7±0.5)kg/m2vs. (19.5±0.3) kg/m2,t =2.12,P =0.031], hemoglobin[(120.0±2.1) g/L vs. (115.0±6.3) g/L, t= 2.12, P= 0.031] and clinical efficacy [95.1 % (39/41) vs. 87.8 % (36/41), χ2= 6.11, P= 0.022]. The incidence of adverse reactions in implantation group was significantly lower than that in control group[29.3 % (12/41) vs. 51.2 %(21/41),χ 2=8.12,P=0.002). The total cost in implantation group was lower than that in control group (138 000 yuan vs. 147 000 yuan, t= 2.09, P= 0.037), and the average hospitalization day was significantly reduced (42.1 d vs. 48.4 d, t = 2.27, P = 0.029). Conclusion Enteral nutrition support with jejunal feeding tube can reduce the incidence of adverse reactions, improve the curative effect, shorten hospitalization time and save medical cost for patients with esophageal cancer.
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Objective To investigate the relationship between type D personality and post-traumatic stress disorder symptoms in survivors after the Zhouqu debris flow disaster.Methods In tatal,213 residents randomly sampled from the Zhouqu debris flow area were assessed one year after disaster.Questionnaires included the posttraumatic stress disorder check list-specific version(PCL-S) and type D personality scale(DS14).Results The prevalence of Type D in the post-disaster sample was 51.17％ accessed by the DS14,compared with 31.1％ prevalence in chinese college students.PTSD symptoms in survivors with type D were significantly severer than those without type D.Initial traumatic feeling,economic loss and negative affectivity were significant predictors of PTSD symptoms in survivors with type D.Conclusion Type D personality is positivel correlated with PTSD and may be a vulnerability factor for PTSD symptoms.
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Objective To investigate the mechanism of inhibitor of calpain on hyperglycemia-induced apoptosis in cultured rat cardiomyocyte.Methods Cardiomyocytes were randomly divided into three groups (control,high glucose,and ALLN).MTT assay was used to detect the viability of cultured cardiomyocytes.Laser confocal microscopy was used to observe the mitochondrial permeable transition and membrane potential.The change of Caspase-3 activity in cardiomyocytes was detected by western blot.Results MTT assay showed that,after 72 h of hyperglycemia,the viability of cardiomyocytes was significantly declined (55％ ± 11％),and the viability in the ALLN pretreatment group was (70％ ± 15％) (P ＜0.05).After hyperglycemia,the mitochondrial permeable transition of cardiomyocyte was increased (30％ ± 15％ vs 60％ ± 11％,P ＜0.05),and membrane potential was declined.Hyperglycemia could increase the expression of cleaved capsase-3,while with pretreatment of ALLN the expression of cleaved caspase-3 was downregulation(0.42 ± 0.11 vs 0.21 ±0.12,P ＜0.05).Conclusions The calpain inhibitor can protect cardiomyocytes from apoptosis under the high glucose condition.
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ObjectiveTo explore the influences of perceived social support and social evaluations( including trust in others,government and social organizations,satisfaction of the government and social organizations,and satisfaction with the disaster relief and reconstruction work)on disaster area adults'life satisfaction after the Yushu earthquake.MethodsWith perceived social support scale (PSSS),satisfaction with life scale (SWLS) and self made survey,370 Tibetan adults were investigated,and the average age was 32.99 ± 12.66.Results ①Perceived fricnds' support( r =0.24,P ＜ 0.01 ),perceived others＇ support ( r =0.15,P ＜ 0.01 ),trust in others,government and social organizations ( r =0.19,P ＜ 0.01 ),satisfaction with the government and social organizations ( r =0.14,P ＜ 0.05) and satisfaction with the disaster relief and reconstruction work ( r=0.17,P ＜ 0.01 )had significant positive correlations with Yushu adults'life satisfaction.②Perceived friends' support ( β =0.21,P ＜ 0.01 )and trust in others,government and social organizations(β =0.27,P＜0.05) were significant predictors of Yushu adults'life satisfaction.ConclusionPerceived friends'support and trust in others,government and social organizations can play an important role in Yushu adults'life satisfaction after the earthquake.
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ObjectiveTo improve the treatment of urethral stricture and evaluate the applicative effects of wire-guided supporting catheterization in clinical urology. MethodsDuring January 2004 and December 2005, the patients with urethral stricture were dwelled with the catheters using the traditional guideless catheterization (group A). If the dwelling failed,it will be replaced by the wire-guided supporting catheterization using the improved catheters. During January 2006 and December 2009, the patients with urethral stricture were dwelled with the improved catheters using wire-guided supporting catheterization ( group B) straightly. Compared the first-time dwelling success incidence,the incidence of catheter associated urinary tract infection and side-effect events. Then after 1 year, compared the urethral stricture recrudescence and the course of treatment. ResultsThe success incidence of first-time catheterization in group A was 48.98％ (24/49) ,and in group B was 97.94％ (95/97) ,there was significant difference between 2 groups;The incidence of catheter associated urinary tract infection in group A was 12.24％, and 8. 25％ in group B, there was significant difference between 2 groups; As for the course of treatment, group A was 46. 2w,group B was 32.7w;The urethral stricture recrudescence in group A and B were 16.33％ and 9.28％ respectively,and there was significant difference between 2 groups. ConclusionThe wire-guided supporting catheterization, which minimize the injury and simplify the operation of internal urethrotomy,could makes the improved catheter easy to induct and replace, improve the success rate of first time-catheterization and prevent the false tunnel damage and new scar expansion. It could make benefit to reduce of incidence of catheter associated urinary tract infection and urethral stricture recrudescence,but also could shorten the course of treatment significantly.
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Objective To explore the changes of indicators for total parenteral nutrition (TPN) and parenteral nutrition (PN) combining enteral nutrition (EN) support in patients with severe acute pancreatitis (SAP), and to analyze the treatment effects of two groups. Methods 29 patients with SAP were randomly divided into two groups: TPN group (n=14) and PN+EN group (n=15). Nonoperative treatment were applied to the two groups. The changes of indicators and therapeutic outcome of two groups were recorded after nutrition support 14 days. Results After 14 days nutritional support, serum albumin (ALB), total serum protein (TSP), blood calcium, glutamic-pyruvic transaminase (ALT), glutamic-oxaloacetic transaminase (AST) in each group increased significantly (P0.05). The APACHE II scores, average hospital days, average hospital charges, incidence of infection and mortality rate in the PN+EN group were significantly lower than that in the TPN group (P<0.05). ConclusionsPN combining EN support was superior to TPN in the treatment of patients with SAP.
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Objective To improve mental health of children in the rural area by intervention with moviewatching.Methods The participants were 438 students from Anhui province,including 273 students in grade 5 from two primary schools and 165 students in grade 2 from two middle schools.Subjects were randomly divided into two groups:an intervention group with movie-watching (n=188)and a control group(n=250).Results The inter-group difference between the pre-measurement and the post-measurement on depression and anxiety of the intervention groups and the control groups in grade 5 from two primary schools was not significant,while the intergroup difference between the pre-measurement and the post-measurement on value8(the intervention group (2669.52±2216.43),the control group(316.57±1410.83)),and the inter-group difference was significant(t_(values)=10.721,P=0.000).The inter-group difference between the pre-measurement and the post-depression, anxiety and values of the interntion groups and the control groups in grade 2from two middle schools was significant(t _(depression)=2.046,P=0.043;t _(state amxoetu)=3.507,P=0.001;t _(trait anxiety)=3.392,P=0.001;t _(values)=5.022,P=0.000)respectively).The intervention effect on mood of depression,anxiety and the values of intervention groups in grade 5 from two primary schools was not significant,while significant on values(F=91.62,P=0.000);while that of intervention groups in grade 2 from two =0.000 respectively).Conclusion Movie-watching intervention wag an effective way to improve middle school students' mental health and to develop correct values.Movie-watching should be an alternative way to improve met-al health of children in rural area for its operability.
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OBJECTIVE@#To investigate the surgical methods to treat maxillary sinus benign diseases with nasal endoscopy.@*METHOD@#Forty-one cases with maxillary sinus benign diseases inducing maxillary sinus polyps, cysts, mycosis, inverted papilloma were operated on using nasal endoscopy in three approaches, such as single pathway of extended ostium of maxillary sinus, two pathway of middle and inferior meatus, two pathway of extended ostium of maxillary sinus and lateral wall of nasal cavity.@*RESULT@#All patients were followed up for a period of more than 6 months, 39 cases were cured (95.1%), 2 cases relapsed.@*CONCLUSION@#Maxillary sinus benign diseases can be excised by three kinds of approaches under nasal endoscopy surgery, and they are minimal invasive effective and worthy of clinical expansion.
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Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Endoscopy , Maxillary Diseases , General Surgery , Maxillary Sinus , General Surgery , Paranasal Sinus Diseases , General SurgeryABSTRACT
Objective To investigate the way off-farm workers show bias on their own group ,rural residents and urban citizens .Method The participants were 78 off-farm workers from 18 to 25 years of age ;The scales and the modified affective priming paradigm were adopted to measure their explicit and implicit attitudes respectively on these groups through recording the participants' reaction on computer .Results (1)The order of three groups sorted by implicit scores in condition of group-relevant words as primes from high to low was urban citizens ,off-farm workers ,rural residents(0.169±0.217,-0.016±0.116,-1.209±1.686 respectively),but the order of explicit scores were reverse(0.7920±1.461,0.4469±1.514,07920±1.461 respectively),and both the difference between the implicit scores and the difference between explicit scores were very significant(between the implicit scores of group bias on off-farm workers and urban citizens:t=7.165,P＜0.01,and on rural residents:t=6.038,P＜0.01;between the explicit scores of group bias on off-farm workers and rural residents:t=9.666,P＜0.01,and on off-farm workers and urban citizens:t=7.828,P＜0.01).(2)The scale scores of group identify ,collective self-esteem and self-esteem were significantly related to the scale scores of group .bias on the off-farm workers and rural residents but not other scores(P＜0.01,P＜0.01,P＜0.05 respectively).Conclusion Although off-farm workers evaluated their own group and rural residents more positively than urban citizens in the obviously way ,they accepted the superiority of urban citizens .implicitly ,and the explicit group-bias was relative to self-esteem ,collective self-esteem and group identify.
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Objective To prepare monoclonal antibody against Prostate Stem Cell Antigen(PSCA) and explore the inhibitory effects of Anti-PSCA mAb in treatments of human prostate cancer xenografts in mice. Methods Balb/c mice were immunized by PC-3 cell line. After fusing and screening, the anti-PSCA McAb’s characterizations were determined. Solid tumors in mice were produced by subcutaneous injection with PC-3 cells in the flanks of the mice.We picked out 10 mice bearing human prostate cancer xenografts.They were divided into a treatment group (n_1=5) and a control group (n_2=5).200 ?g Anti-PSCA mAb was injected into abdominal cavity of each mouse of the treatment group and PBS for them of the control group.Anti-PSCA mAb and PBS were administered once every three days for consecutive three times.The mice survival conditions of two groups were recorded during 5 weeks.The serum PSA, the tumor weights and dimensions of survived mice were measured.The tumor volume inhibition rate was calculated. T-test was performed to compare differences of PSA in serum,tumor weights and volumes between the treatment and control groups.Routine pathological slides of tumor tissue were observed under light microscope to evaluate the range of tumor tissues damaged by Anti-PSCA mAb. Ultrastructure was observed with transmission electron microscope. Results A marine McAb was produced, which raised against PSCA,belonged to IgG1 subclass. The average PSA serum level of the two groups were(3.28?0.55)ng/ml and(7.26?0.43)ng/ml.The weights of tumors of the two groups were(0.95?0.17)g and(3.08?0.18)g.The volumes of them were(164.59?14.08)mm3 and(548.49?19.79)mm3.There are remarkable differences between the treatment group and the control group(P
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Objective: : To observe whether cytokines rIL 2,TNF ?,I FN ? and anti CD3/anti glioma bispecific antibody(BsAb) can work coordinately, and to investigate how to further enhance cytotoxicity of T lymphocyte against human glioma cells by BsAb. Methods: There were 12 groups,contr ast method were used to analyze the effect of cytokines rIL 2,TNF ?,IFN ? to cytoxicity directed by BsAb by single and combined experiments. Cytotoxicity was assayed by standard 18 h 3H TdR incorporation release. Resul ts: rIL 2,TNF ?,IFN ? and BsAb could cooperatively enhance the cy totoxicity of effect cells( P
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Objective: To study bidirectional binding ability and immunoactivity of anti-CD3/anti-glioma bispecific antibodies(BsAb) , and to study its effect on T lymphocytes cells. Methods: Elution from standardized gel column and immnuohistochemical method were used to testify the relative molecular mass of the compound. ELISA method was used to detect its bidirectional immunoactivity and potential T lymphocytes' cytotoxicity. Phenotype and shape of T lymphocytes were also observed. Results: The relative molecular mass of the compound was 110 000, and it combined with both T lymphocytes and glioma cells.Immunoactivity assay showed the compound had good bidirectional immunoactivity. It also enhanced T lympocytes anti-tumor activity. Immunoactivity of BsAb combining with T lymphocytes was 1∶32 000, and combining with glioma cells was 1∶8 000;In phenotypes, CD3 + cells were the major one when cultivated with BsAb/IL-2, CD8 + cells increased gradually with cultivation time. Conclusion: These compounds are bispecific antibodies with bidirectional combining activity to T lymphocytes and glioma cells, they also have bidirectional immunoactivity and can activate T lymphocytes