ABSTRACT
Since reports on GSTO2 polymorphism are still limited, therefore, this study was conducted to investigate an association of genetic polymorphism of GSTO2 and survival for colorectal cancer. Formalin-fixed, paraffin-embedded colorectal cancerous tissues from 26 patients who were continuously followed-up, were used to extract DNA and the gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism. Our findings revealed that the patients carried wild-type GSTO2 gene (N142/N142) had poorer survival rate, when compared with those carried variant GSTO2 gene (adjusted hazard ration, 14.02, P=0.08). No association of GSTO2 genotypes with overall survival was noted (P=0.142). However, this study is only a preliminary report of which the number of cases is small. Further study in a larger population is required to achieve high statistical power and consequently clarify this finding.