ABSTRACT
Disseminated mucormycosis is a rare fungal infectious disease with a high mortality rate and is infrequently diagnosed ante mortem. It is most frequently seen in immunocompromised hosts such as diabetes mellitus, hematologic malignancies, or in the long-term use of steroids or chemotherapeutic agents. Tissue invasion by the hyphae of mucormycosis must be seen microscopically to establish the diagnosis. Treatment consists of correction of the predisposing condition, surgical debridement, and amphotericin-B therapy. A 35-year-old man was admitted through the emergency room due to fever and the right flank pain. He had received an allogenic bone marrow transplantation eight months ago and had been medicated with prednisolone and cyclosporine since the procedure. He was diagnosed with disseminated mucormycosis that involved the spleen, right kidney, and right lung. He is being successfully treated with amphotericin B, flucytosine, and liposomal amphotericin B.
Subject(s)
Adult , Humans , Amphotericin B , Ants , Bone Marrow Transplantation , Bone Marrow , Communicable Diseases , Cyclosporine , Debridement , Diabetes Mellitus , Diagnosis , Emergency Service, Hospital , Fever , Flank Pain , Flucytosine , Hematologic Neoplasms , Hyphae , Immunocompromised Host , Kidney , Lung , Mortality , Mucormycosis , Prednisolone , Spleen , SteroidsABSTRACT
Serious cytomegalovirus (CMV) infection occurs frequently in immunocompromised patients and is a common cause of death. Although primary infection in immunocompetent hosts is normally subclinical, mononucleosis-like syndrome that is characterized by malaise, protracted fever, mild liver function abnormalities, and lymphocytosis with atypical lymphocytes occurs in -10% of patients. Rarely fulminant infection may develop. In both the United States and the United Kingdom, ganciclovir and foscarnet are recommended for the treatment of serious CMV infections in immunocompromised patients. In contrast, there are no recommendations for treatment of severe CMV disease in immunocompetent patients. We describe a case of 45-year-old woman with CMV pneumonia with a fatal outcome for whom there was no evidence of prior immunodeficiency.
Subject(s)
Female , Humans , Middle Aged , Cause of Death , Cytomegalovirus , Fatal Outcome , Fever , Foscarnet , Ganciclovir , United Kingdom , Immunocompromised Host , Liver , Lymphocytes , Lymphocytosis , Pneumonia , United StatesABSTRACT
Pneumonia caused by Mycoplasma pneumoniae is usually a mild and self-limited infection. Chest films usually show patch consolidation or interstitial infiltration in the lung. We recently encountered a case of fulminant Mycoplasma pneumonia which showed rapidly progressing extensive bilateral airspace consolidation with pleural effusion. A previously healthy 19-year-old female college student was admitted to the hospital because of fever and dry cough. Chest X-ray showed large areas of airspace consolidation in both lung with pleural effusion and rapid progression of the lung lesion. The diagnosis of Mycoplasma pneumonia was made from the serologic test. Here we report a case of Mycoplasma pneumonia showing unusual manifestation.