ABSTRACT
BACKGROUND AND OBJECTIVE: Autologous nerve grafting is the conventional technique for bridging nerve gaps. However, the drawback of this technique is the morbidity associated with the left over donor site. The purpose of the present study was to investigate the effects of the turnover distal epineurial sheath tube as an alternative to nerve grafting for the repair of nerve gaps. MATERIAL AND METHOD: The experimental model included 14 male Wistar rats. The left and right sciatic nerves were resected and the 14 left sciatic nerve gaps were reconstructed using conventional autologous nerve grafts while the other 14 right sciatic nerve gaps were reconstructed with turnover distal epineurial sheath tubes. All the repaired sciatic nerves were harvested for histologic and quantitative histomorphometric evaluation at the 11th week after the operations. RESULTS: There were no statistical differences in quantitative evaluation of Schwann cells between the conventional nerve grafting group and the distal epineurial sheath tube group (p > 0.05). CONCLUSION: The turnover distal epineurial sheath tube provides a suitable conduit between two stumps, eliminates donor-site morbidity, reduces the operating time, and might be an alternative modality to nerve grafting for nerve gap repair.
Subject(s)
Animals , Male , Neurosurgical Procedures/methods , Peripheral Nerves/injuries , Rats , Rats, Wistar , Plastic Surgery Procedures/methodsABSTRACT
Preliminary studies for peripheral blood leukocytes and lymphocyte subsets were done in smokers and non-smokers. There were 20 smokers (smoked more than 10 cigarettes per day) for more than a year and 20 non-smokers (smoked less than 20 cigarettes/20 years). Ages of smokers and non-smokers were respectively 21-57, and 18-55 years. Cigarette smoking was associated with a statistically significant increase in the number of neutrophils, activated lymphocytes, CD25 and CD19; but a statistical decrease in the percentage of CD7 and CD3. (P < 0.05)