Role of insulin-like growth factors family in endometrial cancer / 国际肿瘤学杂志

The expression and activity of insulin-like growth factors (IGFs) are increased in endometrial cancer (EC).IGFs not only mediate the positive impact of estrogen on EC,but also increase the risk for development of EC in patients with metabolic disorder.In addition,IGFs play a key role in the invasion,metastasis and drug resistance of EC.Thus,drugs that target IGFs may be the novel treatment of EC.