ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influential factors of total blood loss during unilateral artificial total hip arthroplasty (THA).</p><p><b>METHODS</b>From January 2014 to July 2016, 131 patients undergwent primary unilateral total hip arthroplasty, including 55 males and 76 females, ranging in age from 40 to 89 years old, with an average of 64.5 years old. The data of patients with unilateral total hip arthroplasty were collected, and the data of hemodynamics, coagulation function, hemoglobin and hematocrit values were recorded according to the observation data. The blood loss of the patients was calculated by Gross equation, and the data were analyzed by a statistical software.</p><p><b>RESULTS</b>The total blood loss of the patients was significantly affected by the factors of pathogenesis and deep venous thrombosis of the lower limbs. The results were statistically significant(<0.05). The gender, age, body mass index, prosthesis and anesthesia had little effects on the blood loss volume after replacement.</p><p><b>CONCLUSIONS</b>The data in this study indicate that the volume of actual blood loss can be controlled by adjusting non-surgical factors such as gender, age, body mass index, prosthetic material, and risk factors, and surgical factors(postoperative complications, anesthesia).</p>
ABSTRACT
OBJECTIVE: To investigate the feasibility of cultivated and wild total secoiridoid glucoside in treating osteoarthritis (OA) by observing the effects of total secoiridoid glucoside on interleukin 1β(IL-1β) induced chondrocytes of rat in vitro.