Tadalafil improves total testosterone, IIEF score and SEP in old and middle-aged males with late-onset hypogonadism / 中华男科学杂志

<p><b>OBJECTIVE</b>To observe the clinical effect of tadalafil combined with testosterone undecanoate on late-onset hypogonadism (LOH) in old and middle-aged males.</p><p><b>METHODS</b>A total of 125 old and middle-aged (40 to 60 years) males with LOH were randomly assigned to a treatment group (n = 65) and a control group (n = 60) to be treated with tadalafil + testosterone undecanoate and testosterone undecanoate alone, respectively. We compared the levels of total testosterone (T), IIEF scores and the patients' sexual encounter profile (SEP) diaries before and 4 weeks after medication.</p><p><b>RESULTS</b>The T level, IIEF score and SEP score were significantly improved in both groups after medication as compared with the baseline (P < 0.05), and even more so in the treatment than in the control group (P < 0.05).</p><p><b>CONCLUSION</b>Tadalafil combined with testosterone undecanoate, superior to testosterone undecanoate alone, can improve the T level, IIEF score and SEP score in old and middle-aged males with LOH and increase their sexual satisfaction and self-confidence.</p>

Effects of Seroxat on premature ejaculation: a clinical trial / 中华男科学杂志

<p><b>OBJECTIVES</b>To evaluate the effects of antidepressant Seroxat on premature ejaculation.</p><p><b>METHODS</b>After having taken Seroxat 20 mg every noon for four weeks, the patients were asked to fill the investigating questionaire about the effects and side effects before and after the treatment.</p><p><b>RESULTS</b>After the treatment, 43 cases in our study had increased their ejaculation latency time, enhanced the quality of their sexy lives and their wives', and had significant difference compared with pre-treatment(P < 0.001). They had good effects on improving premature ejaculation after taking Seroxat (11.26 +/- 5.79) days; and after having stopped taking seroxat for (20.94 +/- 8.04) days, the situation of premature ejaculation in 32 cases were as same as that of before. There were seven cases whose sexuality and oomph increased, and two cases whose sexuality were decreased. A few patients had constipation, dry in mouth, insomnia and itch in skin, after taking the drugs.</p><p><b>CONCLUSIONS</b>Antidepressant Seroxat has rather good effects on premature ejaculation and should be used and studied further.</p>